hepatocytes

[International Journal of Stem Cells] Investigators introduced a rat model of liver fibrosis and trans-portal transplantation of human liver stem cells to demonstrate alleviation of liver fibrosis.

[Journal of Hepatology] Scientists investigated the expression and function of annexin A11 in human cholangiocytes and a potential role of IgG1/IgG4-mediated autoreactivity against annexin A11 in the pathogenesis of IgG4-related cholangitis.

[iScience] To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes across different nonalcoholic fatty liver disease stages were profiled, identifying hepatocytes and 12 other non-parenchymal cell types.

[Cell Death & Disease] Scientists evidenced that extracellular vesicles secreted from human hepatocytes attenuated the CCL4-induced acute liver injury by inhibiting the recruitment of monocytes through downregulation of chemokine receptor in the bone marrow and recruitment of neutrophils through the reduction of C-X-C motif chemokine ligand 1 (CXCL1) and CXCL2 expression levels in the liver.

[Stem Cells and Development] Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.

[Cell Death Discovery] Researchers reported that the lymphokine LIGHT/TNFSF14 was upregulated in the murine NAFLD livers and in hepatocytes treated with free fatty acids