insulin

[Cell Reports] Investigators demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributes to glucose-stimulated insulin secretion by mediating cation influx.

[Nature Communications] Scientists applied methods to greatly expand human adipocyte progenitors from small samples of human subcutaneous adipose tissue and then disrupt the thermogenic suppressor gene NRIP1 by CRISPR.

[Cell Metabolism] Using single-cell transcriptomics, the authors identified a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulated in adipose tissue with obesity.

[Science Signaling] Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.

[Journal of Cell Science] Investigators modeled the relationship of adipocytes and endothelial cells in vitro to test the role of insulin in fatty acid transport.

[Diabetes] Scientists assessed the roles of GRP75, other than as a component, in insulin action in both in vitro and in vivo models with insulin resistance.