insulin

[Nature Reviews Endocrinology] Scientists discuss the possible mechanisms responsible for endoplasmic reticulum (ER) proteostasis imbalance with a focus on type II diabetes mellitus, in which both genetics and environment are considered important in promoting ER stress in β-cells.

[Scientific Reports] Investigators developed a human-on-a-chip model composed of human hepatocytes and adipose tissue chambers capable of modeling the metabolic factors that contribute to liver disease development and progression, and evaluation of the therapeutic metformin.

[Amalgam Rx. Inc.] Amalgam Rx, Inc., annocunced global expansion of its insulin titration solution with Novo Nordisk. With Amalgam’s recently received CE Mark for iSage Rx and Dose Check, Novo Nordisk is planning a global expansion.

[Diabetes] Using a transcriptome-wide profiling approach to map translation initiation start sites in human beta-cells under standard and inflammatory conditions, researchers identified a completely new set of polypeptides derived from non-canonical start sites and translation initiation within lncRNA.

[Advanced Science] The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.

[Trends in Endocrinology and Metabolism] Proper material design and biological considerations will improve the success of bioartificial pancreas for regenerative medicine in diabetes.