intestinal epithelial cells

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.

[Chemosphere] Aluminum treatment can regulate intestinal composition and bio-enzyme activity, impairing the function of chemical barrier.

[Scientific Reports] Investigators performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption.

[Scientific Reports] The authors developed a method to isolate viable intestinal epithelial cells, suitable to faithfully measure their metabolic function by determining extracellular glycolytic and mitochondrial flux.

[Cell Death & Disease] Scientists investigated the function of argininosuccinate synthetase (ASS1) in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.

[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.