islets

[Islets] Scientists review the attempts over the past decade, to utilize the organoid cell culture principles in order to identify, expand, and differentiate the adult pancreatic stem cells from different compartments of mouse and human pancreata.

[Molecular Therapy-Nucleic Acids] Scientists experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 upstream neural differentiation-associated RNA. They provided the first evidence that lncRNA-encoded micropeptides played a critical role in pancreatic β cell functions and provided a foundation for future comprehensive analyses of micropeptide function and pathophysiological impact on diabetes.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that convective transport improved nutrient delivery throughout the device and affords a three-dimensional capsule geometry that encapsulates 9.7-fold-more cells than conventional macroencapsulation devices.

[Communications Biology] Scientists demonstrated the utility of the approach by providing volumetric data and 3D distribution of hundreds of thousands of islets of Langerhans within the human pancreas.

[Cell Stem Cell] Scientists enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels isolated from the adipose tissue.

[Cell Stem Cell] Lineage tracing using the Neurogenin3 (Ngn3)-CreERT line identified ductal cells expressing the endocrine master transcription factor Ngn3 that were positive for the δ cell marker somatostatin and occasionally co-expressed insulin.