leukemia cells

[Haematologica] Scientists investigated the oncogenic function of TAL1 and the possible cooperation with PI3K-AKT pathway activation using isogenic pro-T cell cultures ex vivo and in vivo leukemia models.

[Biochemical Pharmacology] Investigators proposed a mechanism by which hydroquinone induced the malignant progression of chronic myeloid leukemia cells.

[Cancer Discovery] In models of AML, leukemia cell differentiation and therapeutic benefit mediated by the histone deacetylases inhibitor panobinostat required activation of the type I interferon pathway.

[Journal of Hematology & Oncology] The role of wild-type isocitrate dehydrogenase-2 (IDH2) in AML cell survival and proliferation was tested using genetic knockdown and pharmacological inhibition in AML cells and animal models.

[Frontiers in Oncology] Investigators found that AML cells released a heterogeneous population of extracellular vesicles containing microRNAs involved in AML pathogenesis.

[Scientific Reports] The authors investigated the relationship amongst PTEN deletion, L-asparaginase sensitivity and glucose metabolism in T cell acute lymphoblastic leukemia cells.