liver cancer

[Communications Biology] The authors investigated cytoskeletal regulation in 2D and 3D culture environments using two liver cancer cell lines, SNU-475 and HepG2, chosen for their distinct cytoskeletal features and invasion profiles.

[Advanced Science] Based on clinical samples, patient-derived cells, and cell lines, it was found that liver cancer cells displayed stem-like characteristics upon glutamine shortage due to maintaining the stemness of tumor initiating cells (TICs) and even promoting transformation of non-TICs into stem-like cells by glutamine starvation.

[Oncogene] Scientists tested the potent inducers of CD4 T helper 1 responses, live-attenuated Listeria monocytogenes ∆actA/∆inlB strain as preventive/therapeutic vaccine candidate in liver fibrosis, HCC, and hepatic cholangiocarcinoma.

[Molecular Cancer Research] Investigators revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARα.

[Scientific Reports] Researchers analyzed angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 expression and localization in human liver cancers and in non-tumor livers.

[iScience] Scientists combined single-cell transcriptomic, proteomic, and chromatin accessibility data to investigate how heterogeneous phenotypes contributed to metastatic potential in five HCC cell lines.