liver fibrosis

[Proceedings of the National Academy of Sciences of the United States of America] Scientists hypothesized that the pace of fibrosis progression might reflect changes in gene expression within the aging liver.

[iScience] Loss of translocator protein in hepatocytes in vitro downregulated acetyl-CoA acetyltransferase 2 and increased free cholesterol.

[Biochemical Journal] Based on mRNA and protein expression profiling data, investigators found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or transforming growth factor β (TGF-β)1-activated primary human hepatic stellate cells.

[Nature Protocols] Researchers describe a protocol to differentiate human induced pluripotent stem cells into hepatic stellate cells.

[Carbohydrate Polymers] Investigators demonstrated that chondroitin sulfate coated multilayered 50-nm nanoparticles encapsulating collagenase and silibinin broke down the dense collagen stroma, while silibinin inhibited activated hepatic stellate cells.

[Acta Pharmaceutica Sinica B] Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.