mass spectrometry

[Proceedings of the National Academy of Sciences of the United States of America] The authors described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.

[Cell] Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer disease brains of multiple cohorts and correlated with disease severity.

[Scientific Reports] Scientists developed a mass spectrometry-based proof-of-concept to assess a histone code screening assay capable of simultaneously detecting multiple hPTM-changes in human ESCs.

[Scientific Reports] Scientists found that enrichment of common organic matrices by black phosphorus could improve discrimination data analysis by enhancing peak intensity and reproducibility of mass spectra acquired from intact cells.

[American Journal of Respiratory and Critical Care Medicine] The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.

[Stem Cells] Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.