neural cells

[Scientific Reports] Researchers demonstrated that phosphatidylcholine-enriched media enhanced neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. They also provided evidence that this phospholipid ameliorated the damage of neurons and modulated neuronal plasticity.

[Neuron] Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.

[Molecular Therapy-Nucleic Acids] The authors provided proof of principle that allele-specific lowering of polyQ-expanded ataxin-3 by selective antisense oligonucleotides was feasible and long lasting with sparing of wildtype ataxin-3 expression in a human cell culture model that was genetically identical to spinocerebellar ataxia type 3 (SCA3) patients.

[Neuron] To investigate neurogenic potential and cellular diversity, scientists profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs.

[Trends in Neurosciences] Scientists review the methods of dynamic morphometrics, consisting of detailed quantification of structural changes of neurons over time, sampling and analyses, focusing on their applications to studies of activity-driven dendritogenesis in vertebrate systems.

[BJU International] Scientists review the prognostic utility of reporting neuroendocrine staining at prostate cancer diagnosis, and determine whether different reporting approaches impact the correlation between staining and patient outcome.