neurons

[Proceedings of the National Academy of Sciences of the United States of America] we demonstrated that Patch-seq technology can be applied both to better understand molecular mechanisms underlying a complex neurological disease at the single-cell level and to provide a platform for screening for therapeutics for the disease.

[Proceedings of the National Academy of Sciences of the United States of America] we show that in mouse hippocampal neurons, dense core vesicles fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.

[Science Advances] we show that optogenetic activation of parvalbumin-positive cells in the medial septal area enabled selective pacing of local field potential oscillations in medial entorhinal cortex.

[PLoS One] To improve treatment of glioblastoma, including those resistant to temozolomide , we explored the potential of targeting dopamine receptor signaling.

[Journal of Cellular and Molecular Medicine] Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.

[Nature Reviews Neurology] Scientists provide an overview of the diverse roles of non-neuronal cells in relation to the pathogenesis of ALS and the emerging potential of non-neuronal cell biomarkers to advance therapeutic development.