obesity

[Scientific Reports] Scientists reported the identification of a novel adenosine monophosphate-activated protein kinase (AMPK) modulator, the indolic derivative IND6, which showed affinity for AMPKα1β1γ1, the primary AMPK isoform in human EA.Hy926 endothelial cells.

[Scientific Reports] Researchers investigated the inhibitory effects and underlying governing mechanism of clitorin in a western diet-induced hepatic steatosis mouse model, and in oleic acid-stimulated HepG2 cells.

[Nature Communications] Investigators showed that the adipocyte secretome upregulated the surface expression of Galectin-9 on human B-acute lymphoblastic leukemia cells which promoted chemoresistance.

[International Journal of Obesity] Abdominal adipose tissue-derived mesenchymal stem cell were harvested from patients without or with obesity during kidney donation or bariatric surgery, respectively.

[Molecular Cell] Scientists showed that the amino acid-induced Ubr1 activity was necessary to prevent steatosis in mouse livers and cultured human hepatocytes, providing molecular insight into the anti-nonalcoholic fatty liver disease effects of dietary protein/amino acids.

[Nature Reviews Neuroscience] The authors review evidence showing that brain inflammation and activation of cellular stress response mechanisms comprise molecular underpinnings of impaired brain insulin signaling in Alzheimer disease (AD) and integrate impaired insulin signaling with AD pathology.