Branched-Chain Amino Acid Aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
[Cell Death & Differentiation]
Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., Gong, A., Wang, D., Cheng, F., & Zhu, H. (2020). Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00644-4 Cite
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Targeting Interleukin-17 Receptor B Enhances Gemcitabine Sensitivity through Downregulation of Mucins in Pancreatic Cancer

Investigators showed interlukine-17 receptor B (IL-17RB) expression was positively correlated with mucin 1 (MUC1) and MUC4 expression in pancreatic cancer cells and tumor tissue.
[Scientific Reports]
Tsai, L.-H., Hsu, K.-W., Chiang, C.-M., Yang, H.-J., Liu, Y.-H., Yang, S.-F., Peng, P.-H., Cheng, W.-C., & Wu, H.-H. (2020). Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer. Scientific Reports, 10(1), 17817. https://doi.org/10.1038/s41598-020-73659-z Cite
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Tumor Treating Fields (TTF) Treatment Enhances Radiation-Induced Apoptosis in Pancreatic Cancer Cells

In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of tumor treating fields and radiotherapy was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival.
[International Journal of Radiation Biology]
Jo, Y., Oh, G., Gi, Y., Sung, H., Joo, E. B., Lee, S., & Yoon, M. (2020). Tumor treating fields (TTF) treatment enhances radiation-induced apoptosis in pancreatic cancer cells. International Journal of Radiation Biology, 0(ja), 1–19. https://doi.org/10.1080/09553002.2020.1838658 Cite
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Anticancer Effects of miR-124 Delivered by BM-MSC Derived Exosomes on Cell Proliferation, Epithelial Mesenchymal Transition, and Chemotherapy Sensitivity of Pancreatic Cancer Cells

miR-124 or EZH2 was overexpressed in AsPC-1 and PANC1 cells. Then, the effects on cell viability, apoptosis, invasion, migration and epithelial mesenchymal transition were evaluated. The roles of miR-124 on the expression and function of EZH2 in pancreatic tumors were determined by dual luciferase reporter assay. Subsequently, miR-124 was transfected to bone marrow mesenchymal stromal cells (BM-MSCs), and the BM-MSCs derived exosomes were isolated and co-cultured with AsPC-1 and PANC1 cells, or injected into pancreatic cancer tumor-bearing mice.
[Aging]
Aging | Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells - Full Text. (n.d.). Retrieved October 15, 2020, from https://www.aging-us.com/article/103997/text Cite
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Neurotensin Receptor 1 Signaling Promotes Pancreatic Cancer Progression

Investigators used sublines to screen molecular targets for the treatment of pancreatic cancer. Among the genes with increased expression levels in the sublines, they focused on those encoding cell surface receptors that may be involved in the interactions between cancer cells and the tumor microenvironment.
[Molecular Oncology]
Takahashi, K., Ehata, S., Miyauchi, K., Morishita, Y., Miyazawa, K., & Miyazono, K. (n.d.). Neurotensin receptor 1 signaling promotes pancreatic cancer progression. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12815 Cite
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Cancer-Associated Fibroblasts in Therapeutic Resistance of Pancreatic Cancer: Present Situation, Predicaments, and Perspectives

The authors analyze the role of cancer associated fibroblasts (CAFs) in therapeutic resistance of pancreatic cancer and discuss potential CAFs-targeting strategies basing on the diverse biological functions of CAFs, thus to improve the outcome of pancreatic cancer treatment.
[Biochimica et Biophysica Acta-Reviews On Cancer]
Han, X., Zhang, W.-H., Wang, W.-Q., Yu, X.-J., & Liu, L. (2020). Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1874(2), 188444. https://doi.org/10.1016/j.bbcan.2020.188444 Cite
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Diltiazem Potentiates the Cytotoxicity of Gemcitabine and 5-Fluorouracil in PANC-1 Human Pancreatic Cancer Cells through Inhibition of P-Glycoprotein

The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
[Life Sciences]
El-Mahdy, H. A., El-Husseiny, A. A., Kandil, Y. I., & Gamal El-Din, A. M. (2020). Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. Life Sciences, 118518. https://doi.org/10.1016/j.lfs.2020.118518 Cite
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Tumor-Associated Macrophages Derived from Cancer Stem Cells

This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
[Acta Histochemica]
Osman, A., Oze, M., Afify, S. M., Hassan, G., EL-Ghlban, S., Nawara, H. M., Fu, X., Zahra, M. H., Seno, A., Winer, I., Salomon, D. S., & Seno, M. (2020). Tumor-associated macrophages derived from cancer stem cells. Acta Histochemica, 122(8), 151628. https://doi.org/10.1016/j.acthis.2020.151628 Cite
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Human Pancreatic Cancer Cells under Nutrient Deprivation Are Vulnerable to Redox System Inhibition

Researchers determined that some small molecular compounds, such as penicillic acid, papyracillic acid, and auranofin, exhibited preferential cytotoxicity to human pancreatic cancer cells under nutrient-deprived compared with nutrient-sufficient conditions.
[Journal of Biological Chemistry]
Onodera, T., Momose, I., Adachi, H., Yamazaki, Y., Sawa, R., Ohba, S., & Kawada, M. (2020). Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition. Journal of Biological Chemistry, jbc.RA120.013893. https://doi.org/10.1074/jbc.RA120.013893 Cite
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TSPAN1 Promotes Autophagy Flux and Mediates Cooperation between WNT-CTNNB1 Signaling and Autophagy via the MIR454-FAM83A-TSPAN1 Axis in Pancreatic Cancer

Scientists demonstrated that TSPAN1 was upregulated in pancreatic cancer and that TSPAN1 depletion decreased pancreatic cancer cell proliferation in vitro and in vivo. TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients.
[Autophagy]
Zhou, C., Liang, Y., Zhou, L., Yan, Y., Liu, N., Zhang, R., Huang, Y., Wang, M., Tang, Y., Ali, D. W., Wang, Y., Michalak, M., Chen, X.-Z., & Tang, J. (2020). TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1826689 Cite
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Long Noncoding RNA TSLNC8 Enhances Pancreatic Cancer Aggressiveness by Regulating CTNNB1 Expression via Association with HuR

Functional experiments demonstrated that tumor suppressor long noncoding RNA on chromosome 8p12 (TSLNC8) promoted pancreatic cancer (PC) cells’ proliferation and invasion in vitro, and enhanced PC growth and metastasis in vivo.
[Human Cell]
Chai, W., Liu, R., Li, F., Zhang, Z., & Lei, B. (2020). Long noncoding RNA TSLNC8 enhances pancreatic cancer aggressiveness by regulating CTNNB1 expression via association with HuR. Human Cell. https://doi.org/10.1007/s13577-020-00429-4 Cite
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