MiR-30d Suppresses Proliferation and Invasiveness of Pancreatic Cancer by Targeting the SOX4/PI3K-AKT Axis and Predicts Poor Outcome

The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease]
Xu, X., Zong, K., Wang, X., Dou, D., Lv, P., Zhang, Z., & Li, H. (2021). miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03576-0 Cite
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MIB1 Upregulates IQGAP1 and Promotes Pancreatic Cancer Progression by Inducing ST7 Degradation

Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology]
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
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The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm

The authors address the current molecular biological features for understanding the multifactorial function of PARP-1 in pancreatic cancer related to the aforementioned roles, along with the summary of recent approaches with PARP-1 inhibition in clinical studies targeting pancreatic cancer.
[International Journal of Molecular Sciences]
IJMS | Free Full-Text | The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm. (n.d.). Retrieved April 6, 2021, from https://www.mdpi.com/1422-0067/22/7/3509 Cite
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SWATH-MS Proteomics of PANC-1 and MIA PaCa-2 Pancreatic Cancer Cells Allows Identification of Drug Targets Alternative to MEK and PI3K Inhibition

Scientists compared PANC-1 and MIA PaCa-2 pancreatic cancer cells which are, respectively, resistant and sensitive to MEK- and PI3K-targeted therapy.
[Biochemical and Biophysical Research Communications]
Aguilar-Valdés, A., Noriega, L. G., Tovar, A. R., Ibarra-Sánchez, M. de J., Sosa-Hernández, V. A., Maravillas-Montero, J. L., & Martínez-Aguilar, J. (2021). SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition. Biochemical and Biophysical Research Communications, 552, 23–29. https://doi.org/10.1016/j.bbrc.2021.03.018 Cite
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Preparation of Multifunctional Nanobubbles and Their Application in Bimodal Imaging and Targeted Combination Therapy of Early Pancreatic Cancer

Researchers explored multifunctional nanobubbles named IR780-NBs-DTX as novel ultrasound contrast agents for dual-mode targeted imaging and photothermal ablation combined with chemotherapy for pancreatic cancer.
[Scientific Reports]
Yang, H., Zhao, P., Zhou, Y., Li, Q., Cai, W., Zhao, Z., Shen, J., Yao, K., & Duan, Y. (2021). Preparation of multifunctional nanobubbles and their application in bimodal imaging and targeted combination therapy of early pancreatic cancer. Scientific Reports, 11(1), 6254. https://doi.org/10.1038/s41598-021-82602-9 Cite
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Pancreatic Cancer Induces Muscle Wasting by Promoting the Release of Pancreatic Adenocarcinoma Upregulated Factor

The authors analyzed the relation between pancreatic cancer-derived pancreatic adenocarcinoma upregulated factor and cancer cachexia in mice and its clinical significance.
[Experimental and Molecular Medicine]
Yoo, W., Choi, H., Son, Y. H., Lee, J., Jo, S., Jung, D., Kim, Y. J., Koh, S. S., Yang, Y. R., Kwon, E.-S., Lee, K.-P., Noh, K. H., Kim, K. W., Ko, Y., Jun, E., Kim, S. C., & Kim, S. (2021). Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor. Experimental & Molecular Medicine, 1–14. https://doi.org/10.1038/s12276-021-00582-2 Cite
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pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer

The authors proposed long-circulating, pH-sensitive nanoparticles composed solely of cellular membrane-disruptive molecules as a new approach for treating pancreatic cancer.
[ACS Applied Materials & Interfaces]
Fan, F., Jin, L., & Yang, L. (2021). pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.0c16576 Cite
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Natural Product Trienomycin A Is a STAT3 Pathway Inhibitor That Exhibits Potent In Vitro and In Vivo Efficacy against Pancreatic Cancer

Researchers identified the natural product Trienomycin A , an ansamycin antibiotic, as a potential inhibitor of the Signal Transducer and Activator of Transcription-3 (STAT3) pathway with potent activity against pancreatic cancer.
[British Journal of Pharmacology]
He, Q.-R., Tang, J.-J., Liu, Y., Chen, Z.-F., Liu, Y.-X., Chen, H., Li, D., Yi, Z.-F., & Gao, J.-M. (n.d.). Natural product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. British Journal of Pharmacology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bph.15435 Cite
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Elevated Levels of Mitochondrial CoQ10 Induce ROS-Mediated Apoptosis in Pancreatic Cancer

Investigators demonstrated that delivery of oxidized Coenzyme Q10 increased mitochondrial Q-pool and was associated with an increase in reactive oxygen species (ROS) generation, effectuating anti-cancer effects in a pancreatic cancer model.
[Scientific Reports]
Dadali, T., Diers, A. R., Kazerounian, S., Muthuswamy, S. K., Awate, P., Ng, R., Mogre, S., Spencer, C., Krumova, K., Rockwell, H. E., McDaniel, J., Chen, E. Y., Gao, F., Diedrich, K. T., Vemulapalli, V., Rodrigues, L. O., Akmaev, V. R., Thapa, K., Hidalgo, M., … Sarangarajan, R. (2021). Elevated levels of mitochondrial CoQ 10 induce ROS-mediated apoptosis in pancreatic cancer. Scientific Reports, 11(1), 5749. https://doi.org/10.1038/s41598-021-84852-z Cite
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Lysosomal Retargeting of Myoferlin Mitigates Membrane Stress to Enable Pancreatic Cancer Growth

Scientists identified the Ferlin family plasma membrane repair factor Myoferlin as selectively and highly enriched on the membrane of pancreatic cancer lysosomes.
[Nature Cell Biology]
Gupta, S., Yano, J., Mercier, V., Htwe, H. H., Shin, H. R., Rademaker, G., Cakir, Z., Ituarte, T., Wen, K. W., Kim, G. E., Zoncu, R., Roux, A., Dawson, D. W., & Perera, R. M. (2021). Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-021-00644-7 Cite
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Mitochondrial Uncoupler MB1-47 Is Efficacious in Treating Hepatic Metastasis of Pancreatic Cancer in Murine Tumor Transplantation Models

Scientists synthesized a new mitochondrial uncoupler MB1-47 and tested its effect on cancer cell metabolism and the anticancer activity in pancreatic cancer cell models and murine tumor transplantation models.
[Oncogene]
Alasadi, A., Cao, B., Guo, J., Tao, H., Collantes, J., Tan, V., Su, X., Augeri, D., & Jin, S. (2021). Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models. Oncogene, 1–11. https://doi.org/10.1038/s41388-021-01688-7 Cite
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