Inhibition of JAK2/STAT3 Signaling Pathway by Panaxadiol Limits the Progression of Pancreatic Cancer

Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[Aging-Us]
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SNAIL2 Contributes to Tumorigenicity and Chemotherapy Resistance in Pancreatic Cancer by Regulating IGFBP2

Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science]
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Propofol Mediates Pancreatic Cancer Cell Activity through the Repression of ADAM8 via SP1

Researchers focused upon the effect of propofol on pancreatic cancer cells and the mechanism by which propofol reduced A disintegrin and metalloproteinase 8 (ADAM8) expression.
[Oncology Reports]
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Cholesterol Biosynthesis Inhibitor RO 48–8071 Inhibits Pancreatic Ductal Adenocarcinoma Cell Viability by Deactivating the JNK and ERK/MAPK Signaling Pathway

RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.
[Molecular Medicine Reports]
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Long Noncoding RNA SOX2OT Promotes Pancreatic Cancer Cell Migration and Invasion through Destabilizing FUS Protein via Ubiquitination

Scientists performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing.
[Cell Death Discovery]
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Long Non-coding RNA ZFAS1 Promotes Pancreatic Cancer Proliferation and Metastasis by Sponging miR-497-5p to Regulate HMGA2 Expression

Scientists identified the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in pancreatic cancer tissues was detected by qRT-PCR.
[Cell Death Discovery]
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A Microenvironment-Inspired Synthetic Three-Dimensional Model for Pancreatic Ductal Adenocarcinoma Organoids

Experimental in vitro models that capture pathophysiological characteristics of human tumors are essential for basic and translational cancer biology. Researchers described a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.
[Nature Materials]
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MAP4K4 Promotes Pancreatic Tumorigenesis via Phosphorylation and Activation of Mixed Lineage Kinase 3

Researchers identified MLK3 as a direct downstream target of MAP4K4. The MAP4K4 and MLK3 associated with each other, and MAP4K4 phosphorylates MLK3 on Thr738 and increased MLK3 kinase activity and downstream signaling.
[Oncogene]
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Combinational Blockade of MET and PD-L1 Improves Pancreatic Cancer Immunotherapeutic Efficacy

Kaplan–Meier plotter was used to analyze the prognostic significance of each of the all-known receptor tyrosine kinases to date in immune “hot” and “cold” pancreatic cancers.
[Journal of Experimental & Clinical Cancer Research]
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circPTPN22 Attenuates Immune Microenvironment of Pancreatic Cancer via STAT3 Acetylation

Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3.
[Cancer Gene Therapy]
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GSK2126458 Has the Potential to Inhibit the Proliferation of Pancreatic Cancer Uncovered by Bioinformatics Analysis and Pharmacological Experiments

Researchers identified key genes and pathways in the development of pancreatic cancer and provide targets for the treatment of pancreatic cancer.
[Journal of Translational Medicine]
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