Invasion Inhibition in Pancreatic Cancer using the Oral Iron Chelating Agent Deferasirox

Researchers used pancreatic cancer cell lines (BxPC-3, Panc-1, and HPAF II) to examine the efficacy of iron chelator deferasirox in preventing invasion in vitro, evaluated using scratch assays and Boyden chamber assays.
[BMC Cancer]
Amano, S., Kaino, S., Shinoda, S., Harima, H., Matsumoto, T., Fujisawa, K., Takami, T., Yamamoto, N., Yamasaki, T., & Sakaida, I. (2020). Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox. BMC Cancer, 20(1), 681. https://doi.org/10.1186/s12885-020-07167-8 Cite
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CircRHOT1 Mediated Cell Proliferation, Apoptosis and Invasion of Pancreatic Cancer Cells by Sponging miR-125a-3p

Investigators demonstrated that circRHOT1 was overexpressed in pancreatic cancer tissues and cell lines, and it was found to directly bind to miR‐125a‐3p, acting as an endogenous sponge to inhibit its activity.
[Journal of Cellular and Molecular Medicine]
Ling, S., He, Y., Li, X., Hu, M., Ma, Y., Li, Y., Lu, Z., Shen, S., Kong, B., Zou, X., Jiang, K., & Huang, P. (n.d.). CircRHOT1 mediated cell proliferation, apoptosis and invasion of pancreatic cancer cells by sponging miR-125a-3p. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15572 Cite
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Additive Clinical Impact of Epidermal Growth Factor Receptor and Podocalyxin-Like Protein Expression in Pancreatic and Periampullary Adenocarcinomas

The effect of transforming growth factor β-induced expression and siRNA-mediated knockdown of podocalyxin-like protein and epidermal growth factor receptor, were investigated in pancreatic cancer cells in vitro.
[Scientific Reports]
Heby, M., Karnevi, E., Elebro, J., Nodin, B., Eberhard, J., Saukkonen, K., Hagström, J., Mustonen, H., Seppänen, H., Haglund, C., Jirström, K., & Larsson, A. H. (2020). Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas. Scientific Reports, 10(1), 1–10. https://doi.org/10.1038/s41598-020-67187-z Cite
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Genome-Wide DNA Methylation Analysis of KRAS Mutant Cell Lines

Scientists analyzed the basal CpG methylation of 11 KRAS-mutant and dependent pancreatic cancer cell lines and observed strikingly similar methylation patterns. KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line.
[Scientific Reports]
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A Synergic Approach to Enhance Long-Term Culture and Manipulation of MiaPaCa-2 Pancreatic Cancer Spheroids

In the field of pancreatic cancer, the MiaPaCa-2 cell line is an interesting model for research but it is known for its difficulty to form stable spheroids; also, when formed, spheroids from this cell line are weak and arduous to manage and to harvest for further analyses such as multiple staining and imaging.The authors compared different methods to evaluate which one allowed to better overpass these limitations.
[Scientific Reports]
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Epigenetic Silencing of AATK in Acinar to Ductal Metaplasia in Murine Model of Pancreatic Cancer

By comparing early mouse pancreatic lesions, non-invasive regions showed apoptosis-associated tyrosine kinase (AATK) co-expression in cells with acinar-to-ductal metaplasia, nuclear VAV1 localization, and cell cycle suppression.
[Clinical Epigenetics]
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Identification of a Novel IL-5 Signaling Pathway in Chronic Pancreatitis and Crosstalk with Pancreatic Tumor Cells

The expression of IL-5R and the effects of IL-5 were analyzed in human and murine tumor cells.
[Cell Communication and Signaling]
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Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]
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Plasma Interleukin-8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer

In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research]
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Seven Bridges and the Pancreatic Cancer Action Network Partner to Develop High-Quality, Actionable Cancer Data Platform

Seven Bridges announced that it has been selected by the Pancreatic Cancer Action Network to build a customized, integrated health data platform to accelerate pancreatic cancer research.
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PharmaCyte Biotech Completes Final cGMP Audit of Manufacturing Facility for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
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