De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.
[Oncogene]
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Interactions with Stromal Cells Promote a More Oxidized Cancer Cell Redox State in Pancreatic Tumors

Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth.
[Science Advances]
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The Inhibition of Panc1 Cancer Cells Invasion by hAMSCs Secretome through Suppression of Tyrosine Phosphorylation of SGK223 (at Y411 Site), C-src (at Y416, Y530 Sites), AKT Activity, and JAK1/Stat3 Signaling

Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.
[Medical Oncology]
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Exosomes: The Key of Sophisticated Cell–Cell Communication and Targeted Metastasis in Pancreatic Cancer

In pancreatic cancer, exosomes are enriched with multiple signaling molecules that mediate intercellular communication with control of immune suppression, mutual promotion between pancreas stellate cells and pancreatic cancer cells, and reprogramming of normal cells.
[Cell Communication and Signaling]
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FGD3 Binds with HSF4 to Suppress p65 Expression and Inhibit Pancreatic Cancer Progression

FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.
[Oncogene]
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Hsa_circ_0074298 Promotes Pancreatic Cancer Progression and Resistance to Gemcitabine by Sponging miR-519 to Target SMOC

Scientists investigate the expression of hsa_circ_0074298 and the molecular mechanism that promoted tumor growth and enhanced the chemoresistance of pancreatic cancer.
[Journal of Cancer]
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Components of the Phosphatidylserine Endoplasmic Reticulum to Plasma Membrane Transport Mechanism as Targets for KRAS Inhibition in Pancreatic Cancer

Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Targeted Intervention of eIF4A1 Inhibits EMT and Metastasis of Pancreatic Cancer Cells via C-MYC/miR-9 Signaling

Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affect EMT and metastasis by joint interference.
[Cancer Cell International]
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Homogeneous Antibody and CAR-T Cells with Improved Effector Functions Targeting SSEA-4 Glycan on Pancreatic Cancer

The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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The Isoflavone Puerarin Exerts Anti-Tumor Activity in Pancreatic Ductal Adenocarcinoma by Suppressing mTOR-Mediated Glucose Metabolism

The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.
[Aging]
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Glucocorticoid Receptor Regulates PD-L1 and MHC-I in Pancreatic Cancer Cells to Promote Immune Evasion and Immunotherapy Resistance

Scientists demonstrated a previously undescribed tumor cell-intrinsic role for glucocorticoid receptor (GR) in activating PD-L1 expression and repressing the major histocompatibility complex class I expression in pancreatic ductal adenocarcinoma cells through transcriptional regulation.
[Nature Communications]
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