pancreatic cells

[Nature Medicine] Researchers achieved high recovery, viability, function and scalability in mouse, porcine, human, and human stem cell-derived beta cell islets by comprehensive optimization of cryoprotectant agent composition, and methods for vitrification and rewarming.

[Cell Death & Disease] Investigators reported that USP49 stability was governed by F-box protein 45 (Fbxo45)-mediated ubiquitination and was enhanced by the absence of Fbxo45.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Nucleic Acids Research] The authors showed that APE1 (apurinic/apyrimidinic endonuclease 1), a multifunctional DNA repair enzyme, is a G4-binding protein, and loss of APE1 abrogated the formation of stable G4 structures in cells.

[Frontiers in Oncology] UHMK1 expression was enhanced in PDAC, and high UHMK1 expression correlated with tumor stage, and lower overall survival.

[Frontiers in Immunology] The authors used multiplex immunofluorescence imaging analysis to characterize MDA5 expression and distribution in pancreatic tissues obtained from 22 organ donors.