prostate cancer

[Prostate Cancer and Prostatic Diseases] Germline mutations in DNA repair genes and KLK3 have been associated with adverse prostate cancer outcomes in separate studies but never jointly. The authors simultaneously assessed these two types of germline mutations.

[Biophysical Journal] The authors showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.

[Telix Pharmaceuticals Limited] In collaboration with Kanazawa University, Telix Pharmaceuticals Limited announced that the Phase I clinical study of the company’s investigational prostate cancer imaging product in Japanese patients has reported the study results. The study has met its objectives, demonstrating safety and tolerability when using TLX591-CDx..

[Molecular Cancer Research] Scientists analyzed irradiation-induced plasticity within the aldehyde dehydrogenase-positive population in prostate cancer.

[Cancer Research] Researchers described a mechanism by which CAF-secreted lactate was able to increase the expression of genes involved in lipid metabolism in prostate cancer cells.

[Cancer Prevention Research] The authors demonstrated that δ-tocotrienol effectively inhibited the development of prostate adenocarcinoma in Ptenp-/- mice, which involved inhibition of proliferation and angiogenesis and promotion of apoptosis.