prostate cancer

[Cell Reports] Researchers defined mesenchymal and stem-like prostate cancer, traced its origin to therapy-induced lineage plasticity, and revealed its sensitivity to HER2/3 inhibition.

[Endocrinology] The authors addressed the species specificity of growth hormone (GH)-GH receptor activity by investigating GH actions in prostate cancer cell lines derived from a mouse Pten deletion model.

[Journal of Experimental & Clinical Cancer Research] Scientists investigated the expression of the protein tyrosine phosphatase receptor type F polypeptide interacting protein alpha 4 (PPFIA4) using public datasets and tumor specimens from prostate cancer cases by immunohistochemistry.

[Nature Reviews Urology] The evolution towards a routine, fully MRI-guided active surveillance pathway has to be preceded by ensuring quality programme assessment for MRI reading and by demonstrating its safety in prospective trials.

[International Journal of Urology] Further study into the “Gut–Prostate Axis” would help in the discovery of new strategies for the prevention, screening, and treatment of prostate cancer.

[Nucleic Acids Research] Mediator 1 (MED1) phosphorylation increased during prostate cancer progression to the lethal phase, and pharmacological inhibition of cyclin-dependent kinase 9 decreased prostate tumor growth by decreasing MED1 phosphorylation and RNA polymerase II recycling.