prostate cancer

[Cell Death Discovery] The authors found that knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists mapped potential pathways for citrate carbons in the human prostate cancer metastasis cell lines LNCaP and VCaP, for which they first established that they secrete citrate.

[Cell Death Discovery] In vitro and in vivo data provided new insights for understanding the mechanisms underlying high-dose-dihydrotestosterone suppression of the enzalutamide-resistant CRPC cell growth, supporting a potential therapy using high-dose-androgens to suppress CRPC progression in the future.

[Cell Reports] Comprehensive mapping of the mTOR chromatin-bound interactome in both androgen-dependent and -independent cellular models of prostate cancer identified a conserved 67-protein interaction network enriched for chromatin modifiers, transcription factors, and SUMOylation machinery.

[Journal of Cancer Research and Clinical Oncology] The authors assessed the function of KMT2C in prostate cancer cell proliferation, colony formation, and migration.

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.