High-Dose-Androgen-Induced Autophagic Cell Death to Suppress the Enzalutamide-Resistant Prostate Cancer Growth via Altering the circRNA-BCL2/miRNA-198/AMBRA1 Signaling

In vitro and in vivo data provided new insights for understanding the mechanisms underlying high-dose-dihydrotestosterone suppression of the enzalutamide-resistant CRPC cell growth, supporting a potential therapy using high-dose-androgens to suppress CRPC progression in the future.