The Canadian Cancer Trials Group (CCTG) announced the commencement of a new sub-study evaluating CFI-400945, an oral, first-in-class inhibitor of Polo-like Kinase 4, in patients with mCRPC.
[Treadwell Therapeutics (Businesswire, Inc.)]
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To discover modulators of androgen receptor (AR)-variant activity, investigtors used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduced AR-driven transcription and proliferation in prostate cancer cells.
[Cell Chemical Biology]
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Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., Stagg, R. A., Curtin, B. H., Chatterjee, D., Mathea, S., Mikochik, P. J., Hopkins, T. D., Gao, H., Branch, J., Xin, H., … Koehler, A. N. (2020). Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2020.10.001 Cite
Scientists demonstrated for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma. Additionally, they showed new tumour suppressive properties of RBMS1 whose observed loss may further elucidate the development of prostate carcinoma.
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Calcitonin gene-related peptide treatment activated extracellular signal-regulated kinases/Signal transducer and activator of transcription 3 signaling in prostate cancer cells.
LINC01006 expression presented high in prostate cancer cell lines. LINC01006 silencing suppressed cell proliferative, migratory, invasive capacities while accelerated apoptotic rate.
[Cancer Cell International]
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PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
[Molecular Biology Reports]
The expression of lysine-specific demethylase 5 A (KDM5A), miR-495, YTHDF2 and MOB3B was validated in human prostate cancer (PCa) tissues and cell lines. Ectopic expression and knockdown experiments were developed in PCa cells to evaluate their effects on PCa cell proliferation, migration, invasion and apoptosis.
[Journal of Experimental & Clinical Cancer Research]
Scientists studied the cytotoxicity and genotoxicity of Mandarin peel oil on Human normal Fibroblast (HFB4) and PC3 prostate cell lines.
[Toxicology Mechanisms and Methods]
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The authors present evidence that in the prostate cancer cell line DU145, the tubules arise in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
[Experimental Cell Research]
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Nolfi, D., Capone, A., Rosati, F., & Della Giovampaola, C. (2020). The alpha-1,2 fucosylated tubule system of DU145 prostate cancer cells is derived from a partially fragmented Golgi complex and its formation is actin-dependent. Experimental Cell Research, 396(2), 112324. https://doi.org/10.1016/j.yexcr.2020.112324 Cite
Researchers investigated the role and mechanisms by which prostate cancer cells induce osteoclastogenesis using cultured monocytic osteoclast precursors.
[Journal of Cellular Biochemistry]
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Scientists observed that DLX6‐AS1 was significantly upregulated in prostate cancer (PCa) tissues and cells. Knockdown of DLX6‐AS1 inhibited PCa progression by suppressing cell proliferation and accelerating cell apoptosis.