Apoptosis-Mediated Anticancer Activity in Prostate Cancer Cells of a Chestnut Honey (Castanea sativa L.) Quinoline–Pyrrolidine Gamma-Lactam Alkaloid

Scientists studied the in vitro inhibitory properties of the tryptophan-derived endogenous metabolite kynurenic acid and of the lactam form of 3–2′-pyrrilonidinyl-kynurenic acid, alkaloids usually present in combination in chestnut honey in two castration-resistant prostate cancer cell lines.
[Amino Acids]
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Pleiotropic Effects of Probenecid on Three-Dimensional Cultures of Prostate Cancer Cells

The authors evaluated the effects of probenecid on 3D-cultures of prostate cancer cells.
[Life Sciences]
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Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters

Scientists investigated the status of glutaminase expression in prostate cancer and correlated expression levels with clinicopathologic parameters.
[Cancers]
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GPR30 Knockdown Weakens the Capacity of CAF in Promoting Prostate Cancer Cell Invasion via Reducing Macrophage Infiltration and M2 Polarization

Cocultured cancer‐associated fibroblasts (CAF)‐shGPR30 and macrophages suppressed prsotate cancer cell invasion compared to cocultured CAF‐shControl and macrophages by decreasing interleukin‐6 (IL‐6) secretion.
[Journal of Cellular Biochemistry]
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Prostate Cancer and Microfluids

Investigators show the vast scope and application of microfluidic systems and how these systems will ensure advancements to future prostate cancer management.
[Urologic Oncology: Seminars and Original Investigations]
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Expression and ERG Regulation of PIM Kinases in Prostate Cancer

Researchers examined the mRNA and protein expression levels of PIM1, PIM2, and PIM3 in prostate cancer and their associations with the MYC and ERG oncogenes.
[Cancer Medicine]
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Phosphorylation of the Androgen Receptor at Ser81 Is Co-Sustained by CDK1 and CDK9 and Leads to AR-Mediated Transactivation in Prostate Cancer

The authors showed that Ser81‐phosphorylated (pS81) androgen receptor (AR) was preferentially localized in the nucleus in both rapid biopsy metastatic castration‐resistant prostate cancer (CRPC) samples and PCa xenografts, and nuclear pS81 localization was correlated with AR transactivation in tumor xenografts.
[Molecular Oncology]
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Prostate Cancer Patient-Derived Organoids: Detailed Outcome from a Prospective Cohort of 81 Clinical Specimens

Investigators report on efforts to generate patient‐derived organoids from a cohort of 81 prostate cancer specimens with diverse pathological and clinical features. They comprehensively analyzed histological features of each enrolled sample and correlated it with organoid growth patterns.
[Journal of Pathology]
Servant, R., Garioni, M., Vlajnic, T., Blind, M., Pueschel, H., Müller, D. C., Zellweger, T., Templeton, A. J., Garofoli, A., Maletti, S., Piscuoglio, S., Rubin, M. A., Seifert, H., Rentsch, C. A., Bubendorf, L., & Magnen, C. L. (n.d.). Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5698 Cite
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NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Investigators showed that the prostate-specific homeoprotein, NKX3.1, suppressed prostate cancer initiation by protecting mitochondria from oxidative stress.
[Cancer Discovery]
Papachristodoulou, A., Rodriguez-Calero, A., Panja, S., Margolskee, E., Virk, R. K., Milner, T. A., Martina, L. P., Kim, J. Y., Bernardo, M. D., Williams, A. B., Maliza, E. A., Caputo, J. M., Haas, C., Wang, V., Castro, G. J. D., Wenske, S., Hibshoosh, H., McKiernan, J. M., Shen, M. M., … Abate-Shen, C. (2021). NKX3.1 localization to mitochondria suppresses prostate cancer initiation. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1765 Cite
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Leptin Antagonism Inhibits Prostate Cancer Xenograft Growth and Progression

Scientists uncovered leptin as a novel universal target in prostate cancer (PCa) and highlighted increased intratumoural leptin and leptin receptor expression in PCa cells and patients’ tumors exposed to androgen deprivation, as observed in patients’ tumors of metastatic and castrate resistant PCa.
[Endocrine-Related Cancer]
Philp, L. K., Rockstroh, A., Sadowski, M. C., Fard, A. T., Lehman, M., Tevz, G., Libério, M. S., Bidgood, C. L., Gunter, J. H., McPherson, S., Bartonicek, N., Wade, J. D., Otvos, L., & Nelson, C. C. (2021). Leptin antagonism inhibits prostate cancer xenograft growth and progression. Endocrine-Related Cancer, 28(5), 353–375. https://doi.org/10.1530/ERC-20-0405 Cite
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A Structure‐Activity Relationship Study of Bimodal BODIPY‐Labeled PSMA‐Targeting Bioconjugates

Researchers identified a high affinity BODIPY peptidomimetic targeting the prostate specific membrane antigen (PSMA) as potential bimodal imaging probe for prostate cancer.
[ChemMedChem]
Stemler, T., Hoffmann, C., Hierleier, I. M., Maus, S., Krause, E., Ezziddin, S., Jung, G., & Bartholomä, M. D. (n.d.). A Structure-Activity Relationship Study of Bimodal BODIPY-labeled PSMA-targeting Bioconjugates. ChemMedChem, n/a(n/a). https://doi.org/https://doi.org/10.1002/cmdc.202100210 Cite
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