Treadwell Announces Initiation of New Clinical Trial of CFI-400945 in Patients with Metastatic Castrate-Resistant Prostate Cancer (mCRPC)

The Canadian Cancer Trials Group (CCTG) announced the commencement of a new sub-study evaluating CFI-400945, an oral, first-in-class inhibitor of Polo-like Kinase 4, in patients with mCRPC.
[Treadwell Therapeutics (Businesswire, Inc.)]
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

To discover modulators of androgen receptor (AR)-variant activity, investigtors used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduced AR-driven transcription and proliferation in prostate cancer cells.
[Cell Chemical Biology]
Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., Stagg, R. A., Curtin, B. H., Chatterjee, D., Mathea, S., Mikochik, P. J., Hopkins, T. D., Gao, H., Branch, J., Xin, H., … Koehler, A. N. (2020). Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2020.10.001 Cite
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Loss of RBMS1 as a Regulatory Target of miR-106b Influences Cell Growth, Gap Closing and Colony Forming in Prostate Carcinoma

Scientists demonstrated for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma. Additionally, they showed new tumour suppressive properties of RBMS1 whose observed loss may further elucidate the development of prostate carcinoma.
[Scientific Reports]
Dankert, J. T., Wiesehöfer, M., Wach, S., Czyrnik, E. D., & Wennemuth, G. (2020). Loss of RBMS1 as a regulatory target of miR-106b influences cell growth, gap closing and colony forming in prostate carcinoma. Scientific Reports, 10(1), 18022. https://doi.org/10.1038/s41598-020-75083-9 Cite
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Neuronal Calcitonin Gene-Related Peptide Promotes Prostate Tumor Growth in the Bone Microenvironment

Calcitonin gene-related peptide treatment activated extracellular signal-regulated kinases/Signal transducer and activator of transcription 3 signaling in prostate cancer cells.
[Peptides]
Zhu, W., Sheng, D., Shao, Y., Zhang, Q., & Peng, Y. (2021). Neuronal calcitonin gene-related peptide promotes prostate tumor growth in the bone microenvironment. Peptides, 135, 170423. https://doi.org/10.1016/j.peptides.2020.170423 Cite
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LINC01006 Facilitates Cell Proliferation, Migration and Invasion in Prostate Cancer through Targeting miR-34a-5p to Up-Regulate DAAM1

LINC01006 expression presented high in prostate cancer cell lines. LINC01006 silencing suppressed cell proliferative, migratory, invasive capacities while accelerated apoptotic rate.
[Cancer Cell International]
Ma, E., Wang, Q., Li, J., Zhang, X., Guo, Z., & Yang, X. (2020). LINC01006 facilitates cell proliferation, migration and invasion in prostate cancer through targeting miR-34a-5p to up-regulate DAAM1. Cancer Cell International, 20(1), 515. https://doi.org/10.1186/s12935-020-01577-1 Cite
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Rosuvastatin Inhibit Spheroid Formation and Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer PC-3 Cell Line

PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
[Molecular Biology Reports]
Deezagi, A., & Safari, N. (2020). Rosuvastatin inhibit spheroid formation and epithelial–mesenchymal transition (EMT) in prostate cancer PC-3 cell line. Molecular Biology Reports. https://doi.org/10.1007/s11033-020-05918-1 Cite
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Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B Axis Facilitates Prostate Cancer Progression

The expression of lysine-specific demethylase 5 A (KDM5A), miR-495, YTHDF2 and MOB3B was validated in human prostate cancer (PCa) tissues and cell lines. Ectopic expression and knockdown experiments were developed in PCa cells to evaluate their effects on PCa cell proliferation, migration, invasion and apoptosis.
[Journal of Experimental & Clinical Cancer Research]
Du, C., Lv, C., Feng, Y., & Yu, S. (2020). Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. Journal of Experimental & Clinical Cancer Research, 39(1), 223. https://doi.org/10.1186/s13046-020-01735-3 Cite
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Estimation of Mandarin Peel Oil Induced Cytotoxicity and Genotoxicity in Human Normal Fibroblast and Cancerous Prostate Cell Lines

Scientists studied the cytotoxicity and genotoxicity of Mandarin peel oil on Human normal Fibroblast (HFB4) and PC3 prostate cell lines.
[Toxicology Mechanisms and Methods]
Hussien, N. A., & Mohamed, H. R. H. (2020). Estimation of Mandarin Peel Oil induced Cytotoxicity and genotoxicity in Human Normal Fibroblast and Cancerous Prostate Cell Lines. Toxicology Mechanisms and Methods, 0(ja), 1–20. https://doi.org/10.1080/15376516.2020.1836103 Cite
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The Alpha-1,2 Fucosylated Tubule System of DU145 Prostate Cancer Cells Is Derived from a Partially Fragmented Golgi Complex and Its Formation Is Actin-Dependent

The authors present evidence that in the prostate cancer cell line DU145, the tubules arise in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
[Experimental Cell Research]
Nolfi, D., Capone, A., Rosati, F., & Della Giovampaola, C. (2020). The alpha-1,2 fucosylated tubule system of DU145 prostate cancer cells is derived from a partially fragmented Golgi complex and its formation is actin-dependent. Experimental Cell Research, 396(2), 112324. https://doi.org/10.1016/j.yexcr.2020.112324 Cite
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Delineating Role of NF-κB and Interacting Cytokines during Prostate Cancer-Induced Osteoclastogenesis

Researchers investigated the role and mechanisms by which prostate cancer cells induce osteoclastogenesis using cultured monocytic osteoclast precursors.
[Journal of Cellular Biochemistry]
Jadli, M., Thakur, K., Aggarwal, N., Chhokar, A., Bibban, R., Singh, T., Bhat, A., & Bharti, A. C. (n.d.). Delineating role of NF-κB and interacting cytokines during prostate cancer-induced osteoclastogenesis. Journal of Cellular Biochemistry, n/a(n/a). https://doi.org/10.1002/jcb.29856 Cite
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DLX6-AS1 Accelerates Cell Proliferation through Regulating miR-497-5p/SNCG Pathway in Prostate Cancer

Scientists observed that DLX6‐AS1 was significantly upregulated in prostate cancer (PCa) tissues and cells. Knockdown of DLX6‐AS1 inhibited PCa progression by suppressing cell proliferation and accelerating cell apoptosis.
[Environmental Toxicology]
Zhu, X., Ma, X., Zhao, S., & Cao, Z. (n.d.). DLX6-AS1 accelerates cell proliferation through regulating miR-497-5p/SNCG pathway in prostate cancer. Environmental Toxicology, n/a(n/a). https://doi.org/10.1002/tox.23036 Cite
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