Targeting IL-11 to Reduce Fibrocyte Circulation and Lung Accumulation in Animal Models of Pulmonary Hypertension-Associated Lung Fibrosis

Human fibrocytes were isolated from peripheral blood of six healthy donors. Recombinant human (rh)-IL-11 and soluble rh-IL-11 receptor, α subunit were used to stimulated fibrocytes in vitro to measure cell migration in a chemotactic migration chamber among other variables.