prostate cells

[Chemical Biology & Drug Design] Scientists evaluate the first preclinical and clinical studies on prostate-specific membrane antigen (PSMA) ligands resulting future perspectives radiolabeled PSMA in staging and molecular characterization, based on histopathologic examinations of PSMA expression.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists performed comparative transcriptomics of 1) isogenic androgen receptor (AR)-positive versus AR-negative prostate cancer cells, 2) AR-positive versus AR-negative prostate cancer tumors, and 3) isogenic JMJD1C-expressing versus JMJD1C-depleted AR-negative prostate cancer cells.

[Febs Open Bio] The role of heme oxygenase-1 (HO-1) in interrupting M. hyorhinis replication was confirmed by HO-1-specific siRNA suppression of hemin-induced HO-1 protein expression, which increased intracellular M. hyorhinis DNA levels in LNCaP cells.

[Oncogene] Through functional, transcriptomic, epigenomic, and proteomic analyses, researchers showed that prolyl hydroxylation of YAP1 played a critical role in the suppression of cell migration, invasion, and metastasis in prostate cancer.

[International Journal of Biological Macromolecules] Scientists reported the molecular interactions of indoline derivative, HIC, with P2Y1R. In vitro analysis has shown increased apoptosis of PCa-cells, PC3, and DU145, upon specific interaction of P2Y1R-HIC.

[Cancer Immunology] To identify long-term changes in gene expression after irradiation, PC3 and LNCaP prostate cancer cells were irradiated with either a single dose or a fractionated regimen of 10 fractions.