Publication

[Genome Medicine] Single-cell RNA sequencing analysis showed that the top four differentially and selectively expressed genes in human islet endocrine cells in vitro and in vivo were not the canonical genes but a new set of non-canonical gene markers.

[Biomedicine & Pharmacotherapy] The authors explored the effect of cordycepin, a natural adenosine isolated from Cordyceps militaris, on high glucose/lipid-induced glucotoxicity and lipotoxicity in INS-1 cells.

[iScience] Inhibition of USP1 either by genetic intervention or small molecule inhibitor ML323 restored epithelial phenotype of β-cells, but not with inhibition of other deubiquitinases.

[Advanced Materials] By gaining the targeting ability of stem cells against pancreatic tumor cells, stem cell membranes encapsulated nano polylactide-co-glycolide loaded with doxorubicin to target and reduce deep pancreatic tumor tissues.

[Cancer Letters] Scientists explored the mechanism of chemotherapy-induced pyroptosis and elucidated the role of pyroptosis in mediating PDAC progression and chemoresistance.

[Oncogenesis] Researchers demonstrated that retinoic acid receptor β transcriptionally repressed myosin light chain 2 expression in pancreatic cancer cells.