Publication

[Nature Communications] Scientists demonstrated the usefulness and necessity of a pooled design to reveal donor iPSC line heterogeneity during macrophage cell differentiation and to model rare WT1 mutation-driven kidney disease with chimeric organoids.

[Cell Stem Cell] Researchers constructed human blood-brain barrier (hBBB) assembloids from brain and blood vessel organoids derived from human pluripotent stem cells. They validated the acquisition of BBB-specific molecular, cellular, transcriptomic, and functional characteristics and uncovered extensive neuro-vascular crosstalk with a spatial pattern within hBBB assembloids.

[Nature Cancer] Using infusion products of individuals with large B cell lymphoma, the authors integrated functional profiling using timelapse imaging microscopy in nanowell grids with subcellular profiling and single-cell RNA sequencing to identify a signature of multifunctional CD8+ T cells.

[Acta Pharmacologica Sinica] Researchers used vascular smooth muscle-specific leucine-rich repeat-containing family 8 A (LRRC8A) knockout mice and an angiotensin II-induced hypertension model.

[Cell] The authors revealed a direct differentiation pathway from HSCs into platelets that is progressively propagated upon aging. The aging-enriched platelet path was decoupled from all other hematopoietic lineages, including erythropoiesis, and operated as an additional layer in parallel with canonical platelet production.

[Cell Stem Cell] Scientists demonstrated that autophagy was an adaptive cytoprotective response to chronic inflammation in the aging murine bone marrow niche.