Publication

[European Heart Journal] Scientists identified endothelial cells as predominant signal-sending cells with extensive fibroblasts connectivity in both sinus rhythm and atrial fibrillation atrial tissues.

[Molecular Cancer] Researchers identify two distinct but interconnected activin receptor-like kinase 7 (ALK7)-driven non-canonical pathways that promote PDAC dissemination.

[Science Advances] Integrating multicenter patient data and multi-omics, scientists reported that the misp53^R273H/C mutant is associated with cell cycle progression and a basal-like state compared to the misp53R248W/Q mutant.

[Gene] Scientists validated the role of origin recognition complex (ORC) 6 in PDAC and supported the hypothesis that the METTL3/IGF2BP3/ORC6/p53 axis may be a novel therapeutic target for PDAC, and inhibiting this axis may be an advantageous therapeutic strategy for curing PDAC.

[Molecular Pharmaceutics] Researchers confirmed the overexpression of 5T4 protein in tumor samples of pancreatic adenocarcinoma compared with the corresponding paraneoplastic tissue.

[Molecular Carcinogenesis] Pancreatic cancer cells were exposed to increasing concentrations of nigericin at different time periods, and the corresponding 50% inhibiting concentration values were calculated.