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ANKRD1 Sustains a Neurogenic BMSC Niche and Counters Cognitive Aging

[International Journal of Oral Science] Researchers explored a neural crest-like progenitor niche in bone marrow MSCs with high neurogenic and proliferative capacity by single-cell transcriptomics.

Fusogenic Hybrid Gelled Nanovesicles Combining Mesenchymal Stromal Cell Cargo with Cholesterol-Modified Macrophage Membranes for Targeted Myocardial Infarction Therapy

[ACS Nano] Scientists developed a hybrid gelled nanovesicle, Hy-gNVs@chol, through chitosan-based protein enrichment and functional membrane replacement, enabling efficient concentration of MSC components to form gel nanoparticles while conferring inflammation-targeting capability.

Global Metabolomics Identifies New Extracellular Biomarkers of Nanovibration-Driven Mesenchymal Stem Cells Osteodifferentiation

[Biomaterials Advances] As part of an effort to eliminate synthetic osteogenic compounds, the authors characterized the metabolic adaptations of MSC to chemical-free nanovibration-induced osteodifferentiation.

Apoptotic Bodies Derived from Human Umbilical Cord Mesenchymal Stem Cells Improve Recovery from Myocardial Infarction in Swine

[Autophagy] Researchers investigated the therapeutic effects of apoptotic bodies derived from human umbilical cord MSCs on cardiac recovery in a porcine model of myocardial infarction.

METTL3-m6a-STAT1/NF-κB Axis: A Key Switch for the Immunosuppressive Capacity of Mesenchymal Stem Cells

[Cellular & Molecular Biology Letters] This study established METTL3 as a critical regulator of the immunosuppressive capacity of MSCs, mediated through inducible nitric oxide synthase expression.

Synergistic Effects of Aligned PCL/rGO Scaffolds and Electrical Stimulation on BMSC Neuronal Differentiation

[Journal of Biomaterials Applications] A synergistic bio-electroactive platform was established to specifically induce neuronal differentiation from bone marrow MSCs by coupling spatially oriented, conductive polycaprolactone/reduced graphene oxide nanofibrous scaffolds with exogenous electrical stimulation.

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