Publication

[Journal of Leukocyte Biology] By specific deletion of Rictor in CD11c+ myeloid cells, researchers investigated the role of mTOR complex 2 (mTORC2) signaling in dendritic cell function in mice.

[Journal Of Clinical Investigation] Investigators showed that NLR family CARD Domain Containing 4 (NLRC4) was downregulated in epithelial tumor cells of colorectal cancer patients by using spatial tissue imaging.

[FEBS Journal] The authors revealed that, in zebrafish hematopoiesis, L-threonine dehydrogenase (tdh) was preferentially expressed in neutrophils.

[Science Signaling] Researchers investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. They found that tumor necrosis factor–α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression of a metabolic transcriptome.

[JCI Insight] Scientists investigated the potential of extracellular vesicles derived from human gingival mesenchymal stem cells as a therapeutic strategy for rheumatoid arthritis.

[American Journal Of Physiology-Cell Physiology] To determine how the baseline O2 level affected the subsequent response to hypoxia, scientists cultured PC-3 prostate cancer cells in either 18% or 5% O2 for two weeks prior to exposing them to hypoxia for 12-48 hours.