Publication

[EMBO Journal] Scientists discovered that the loss of YTHDF2 in Treg cells reduced tumor growth in mice, and that deletion of Ythdf2 in Tregs did not affect peripheral immune homeostasis, but led to increased apoptosis and impaired suppressive function of Treg cells in the tumor microenvironment.

[Circulation Research] Using macrophage-specific Rictor- and mTOR-deficient mice, investigators dissected the distinct functions of mTORC2 pathways in atherogenesis.

[Cancer Immunology Research] An EGFR-Vδ2 bispecific T-cell engager was generated and its capacity to activate Vγ9Vδ2 T cells and trigger antitumor activity were tested in multiple in vitro, in vivo, and ex vivo models.

[Nature] The authors reported that both dietary factors and microbial factors influenced the level of gut linoleic acid isomers, and that conjugated linoleic acid in turn modulated a distinct population of CD4+ intraepithelial lymphocytes that expressed CD8αα in the small intestine.

[Science Translational Medicine] Scientists validated triggering receptor expressed on myeloid cells 1 (TREM1) as a specific marker of proinflammatory, central nervous system-infiltrating, peripheral myeloid cells in mice with experimental autoimmune encephalomyelitis.

[Cell] Combining structural biology and in vivo analysis in coral and oyster animals, researchers explained how synthesis of distinct nucleotide signals enabled cells to control discrete cGAS-like receptors-STING signaling pathways.