Publication

[BMC Cancer] knocked out Brd4 in tumor organoids carrying mutations in Apc and Kras to generate Brd4KO organoids, and performed RNA-seq.

[Scientific Reports] Scientists utilized global microRNA (miRNA) expression profiling to identify specific miRNAs responsible for reprogramming normal lung fibroblasts into cancer-associated fibroblasts.

[Nature Immunology] Scientists analyzed the relative contributions of CD4+ regulatory T cells expressing Forkhead box protein P3 and CD8sup>+ regulatory T cells expressing killer cell immunoglobulin-like receptors to the control of autoreactive T and B lymphocytes in human tonsil-derived immune organoids.

[Nature Cancer] Scientists demonstrated a decisive role for ETS variant 7 (ETV7) in driving CD8+T cell terminal exhaustion and revealed that ETV7 may be a promising target and biomarker for improving the efficacy of cancer immunotherapy.

[Journal of Clinical Investigation] Investigators demonstrated that endothelial stimulator of interferon genes (STING) expression was critical for STING agonist-induced antitumor activity. STING activation in endothelium promoted vessel normalization and CD8+ T cell infiltration but not IFN-γ or CD4+ T cells.

[Kidney international] Scientists investigated whether Tregs engineered to express glomerular basement membrane-T cell receptors specific for α3(IV)NC1135- 145 better suppress autoimmunity.