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Gastric Cancer Mesenchymal Stem Cells Promote Tumor Glycolysis and Chemoresistance by Regulating B7H3 in Gastric Cancer Cells

[Journal Of Cellular Biochemistry] Glucose uptake and lactate production assays were used to evaluate the importance of B7H3 expression in gastric cancer MSCs-treated gastric cancer cells. The therapeutic efficacy of oxaliplatin and paclitaxel was determined using CCK-8 and colony formation assays.

MicroRNA-124a Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells into Neurons

[Journal of Receptors and Signal Transduction] Scientists investigated the effects of microRNA-124a on the differentiation of bone marrow MSCs and its underlying mechanism.

Metformin and Adipose-Derived Stem Cell Combination Therapy Alleviates Radiation-Induced Skin Fibrosis in Mice

[Stem Cell Research & Therapy] Researchers conducted a comprehensive study to assess the effectiveness of metformin and adipose-derived stem cells, whether autologous or allogeneic, individually or in combination therapy, in mitigating radiation-induced skin fibrosis.

Uncovering Potential Diagnostic and Pathophysiological Roles of α-Synuclein and DJ-1 in Melanoma

[Cancer Medicine] Scientists investigated the molecular mechanisms through which α-synuclein and DJ-1 interact, suggesting novel biomarkers and targets in melanoma.

Genomic and Transcriptomic Analysis of Breast Cancer Identifies Novel Signatures Associated with Response to Neoadjuvant Chemotherapy

[Genome Medicine] Reserachers performed whole-exome and RNA sequencing on 233 samples from 50 breast cancer patients with rigorously defined responses to neoadjuvant chemotherapyand analyzed changes in the multi-omics landscape.

RUNX2 Prompts Triple Negative Breast Cancer Drug Resistance through TGF-β Pathway Regulating Breast Cancer Stem Cells

[Neoplasia] Scientists took a multifaceted approach from in vitro and in vivo experiments to validate the relationship between RUNX2 and TGF-β and to search for their pathogenic mechanisms in chemoresistance.

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