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Genomic Classifiers and Prognosis of Localized Prostate Cancer: A Systematic Review

[Prostate Cancer And Prostatic Diseases] Genomic classifiers provide a small but consistent improvement upon the prognostic ability of clinical classification schemes, which may be helpful when treatment decisions are uncertain.

Peroxisomal Ī²-Oxidation Enzyme, DECR2, Regulates Lipid Metabolism and Promotes Treatment Resistance in Advanced Prostate Cancer

[British Journal of Cancer] The impact of 2,4-dienoyl CoA reductase 2 (DECR2) and peroxisomal Ī²-oxidation inhibition via thioridazine was examined in vitro, in vivo, and in clinical prostate tumours cultured ex vivo.

TrkA Promotes MDM2-Mediated AGPS Ubiquitination and Degradation to Trigger Prostate Cancer Progression

[Journal Of Experimental & Clinical Cancer Research] CCK8 assay and colony formation assay were used to illustrate the key role of AGPS in the progression of prostate cancer in vitro.

Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-Free DNA Methylation

[Cancer Discovery] Researchers developed a targeted DNA methylation assay to detect castration-resistant neuroendocrine prostate cancer (CRPC-NE) using plasma cell-free DNA, which quantified tumor content and provided a phenotype evidence score that captured diverse CRPC phenotypes, leveraging regions to inform transcriptional state.

Distinct Mesenchymal Cell States Mediate Prostate Cancer Progression

[Nature Communications] Scientists employed single-cell RNA sequencing to delineate molecular changes in tumor stroma that influence prostate cancer progression and metastasis.

Serine/Threonine Kinase 36 Induced Epithelial-Mesenchymal Transition Promotes Docetaxel Resistance in Prostate Cancer

[Scientific Reports] To investigate the role of erine/threonine kinase 36 on cell proliferation, invasion, and migration, erine/threonine kinase 36 was overexpressed and silenced in DU-145 and PC-3 cell lines.

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