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[VectorY Therapeutics] VectorY Therapeutics announced that the first participant has been dosed in its Phase 1/2 PIONEER-ALS trial evaluating VTx-002, a first-in-class vectorized antibody targeting TDP-43 pathology in people with ALS.

[Nature Cell Biology] Investigators used live-cell microscopy to examine the impact of Parkinson’s disease associated lipid alterations on α-synuclein release. They discovered that increased glucosylceramides as a consequence of reduced β-glucocerebrosidase activity induce ectosome shedding from primary neurons.

[Cell Death & Disease] Scientists demonstrated that heat shock protein family A member 5 (HSPA5) expression was highest in the mesenchymal subtype of glioblastoma. The overexpression of HSPA5 in proneural cells induced proneural-to-mesenchymal transition and promoted malignant phenotypes.

[Journal of Translational Medicine] The authors investigated the upstream regulatory mechanisms of N-Myc stabilization in neuroblastoma and explored potential therapeutic strategies targeting these mechanisms.

[Journal of Medicinal Chemistry] Investigators established paroxetine as a functional heat shock protein 27 (HSP27) inhibitor that disrupts the interaction between HSP27 and MMP-2/9, thereby inhibiting glioblastoma progression.

[Scientific Reports] Researchers found that Wnt-3a alone had no effect on pro-inflammatory TNF-α or IL-1β release from homeostatic primary microglia, however co-administration with LPS significantly increased TNF-α release beyond that seen with LPS alone.

[Journal of Biomedical Science] Scientists provide a comprehensive introduction to the structure, neurotoxicity, regulatory mechanism, and relevance of APP-C31 to clinical diseases and its therapeutic potential as a drug target.

[Experimental & Molecular Medicine] Investigators highlight advances in modeling MS progression, using human induced pluripotent stem cell-derived systems, with a particular focus on microglia as key mediators of neuroinflammation and neurodegeneration.

[Discover Oncology] The authors summarize resistance-associated changes across three key areas – glycolysis, redox homeostasis, and lipid metabolism in temozolomide-resistant glioblastoma.

[Biomacromolecules] Investigators demonstrated the construction of poly(ethylene glycol)-derived hydrogels by efficient cross-linking of quinolinium acyltrifluoroborate-functionalized macromers with a partner hydroxylamine-functionalized macromer.

[Cancer Gene Therapy] The authors engineered MSCs to deliver the immuno-stimulatory TNF superfamily ligand LIGHT (MSC-L). They found that MSC-L simultaneously primed immune responses against both tumor cells and cancer-associated fibroblasts.

[Scientific Reports] Scientists assessed the effect of circulatory bone marrow derived-MSCs on proliferation, migration, invasion, tumor growth, and metastasis of oral squamous cell carcinoma cells.