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[28bio (BioSpace)] 28bio announced CNS-3D Inflammatory Organoids, designed to evaluate efficacy of anti-inflammatory drugs by quantifying their ability to reduce inflammatory injury, preserve tissue health, and restore neuronal network activity.

[Cell Stem Cell] Researchers generated human amygdala-like telencephalic organoids (hATOs) that recapitulated cellular composition, region-specific development, and key features of the amygdala. They highlight the potential of hATOs to understand molecular features of affective circuitry underlying emotion.

[Developmental Cell] Scientists established a stable biobank of 16 long-term cultured appendiceal adenocarcinoma (AC) patient-derived tumor organoids. Single-cell profiling reveals dedifferentiation from differentiated states in primary AC into intestinal stem cell and fetal progenitor states in AC-peritoneal carcinomatosis, with upregulation of oncogenic signaling pathways.

[Ecotoxicology and Environmental Safety] The authors established a hPSC-derived airway organoid platform and systematically compared the toxicological profiles of two heated tobacco product aerosols.

[Cell Biomaterials] The application of skin organoid models in the biomedical field is of great significance for the treatment of rare diseases such as genetic diseases, the tissue repair of large wounds caused by scleroderma or frostbite, and patient-specific drug screening.

[Cell Biomaterials] This review summarizes recent strategies for incorporating vascular, neural, and immune components into organoids and for assembling multiple organoid types. Scientists discusss key factors of assembloid formation, such as cell source, intercellular interactions, cytokine signaling, and extracellular matrix properties.

[Advanced Science] Researchers presented a stretchable 3D microelectrode array with microneedles fabricated via a scalable wafer-level stud-bump bonding process for minimally destructive and stable monitoring. They achieve high-fidelity, reliable electrophysiological recordings of both human iPSC-derived heart and cerebral models.

[Cell Stem Cell] Functional restoration of vision in adult mammals remains unattainable following complete transection of the optic nerve. In this study, scientists addressed this challenge by heterotopically transplanting human retinal organoids into the transection cavity of the optic nerve in adult rats.

[Stem Cell Research & Therapy] The authors discuss the biomedical applications of organoids, including in vitro disease models, infectious diseases, cancer, drug screening, and toxicity testing, tissue engineering, and age-related diseases.

[Microsystems & Nanoengineering] Scientists developed a multilayered microelectrode arrays (MLMEA) capable of interfacing with multiple depths within brain organoids. They demonstrate that MLMEA can reliably capture heterogeneous, depth-dependent neuronal activity.

[Journal for Immunotherapy of Cancer] Researchers investigated the potential non-pyroptotic mechanism of action of gasdermin D (GSDMD) in preventing prostate cancer (PCa) immune evasion. They revealed a novel non-pyroptotic pathway through which GSDMD inhibits PCa immune evasion by targeting laminin subunit gamma-2 (LAMC2) for degradation.

[Nature Reviews Urology] Spatial transcriptomics enables the characterization of tumor architecture using spatial resolution at the single-cell or multi-cell level. These approaches also permit bioinformatic inference of large-scale copy number variants, enabling integrated genomic–transcriptomic analysis of clonal evolution and therapy resistance.