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[European Heart Journal] Human induced pluripotent stem cell-derived cardiomyocytes from each index short QT syndrome patient were developed, as well as an isogenic cell line with variant correction and HEK 293T cells transfected with SLC4A3 expression constructs expressing either wild type SLC4A3 or the variants.

[Biosensors & Bioelectronics] The synthesis of the cardioactive drug propranolol from its precursor was chosen and successfully established in a continuous microfluidic setup. For sensitive detection of bioactivity, human stem cell-derived cardiomyocyte 3D cultures were used.

[Nature Metabolism] Researchers revealed spatiotemporal dynamics of phosphofructokinase 1, a key glycolytic enzyme, within the skeletal muscle lineage.

[Biomaterials] Scientists highlighted that human pre-vascularized microtissue can effectively re-establish the vascular regenerative microenvironment, which presented an innovative therapeutic approach to promote functional skeletal muscle regeneration following volumetric muscle loss.

[Journal of Translational Medicine] Excessive AMPK activity, in the context of impaired AdipoR2 function, contributes to redox imbalance and metabolic dysfunction in the skeletal muscle, favoring a “senescent-like” phenotype.

[JCI Insight] Investigators showed that GLP-1 receptors (GLP-1Rs) in vascular smooth muscle cells are essential for semaglutide-mediated blood pressure (BP) reduction in mice. In contrast, GLP-1Rs in Tie2+ endothelial or immune cells are not required for semaglutide to lower BP.

[Biochemistry and Biophysics Reports] Researchers suggests that water-soluble compounds from Salacia may prevent or attenuate sphingosylphosphorylcholine-induced vasospasm and its associated severe vascular diseases.

[Biochemical Pharmacology] The authors elaborate on the central position and “double-edged sword” role of the cGAS–STING pathway in skeletal muscle pathophysiology.

[Dyne Therapeutics, Inc.] Dyne Therapeutics, Inc. announced the initiation of the Phase III HARMONIA trial of zeleciment basivarsen, in individuals with DM1.

[European Heart Journal] Researchers investigated epigenetically regulated mechanisms underlying endothelial cell-dependent cardiac aging and identified a critical role for zinc finger and BTB domain-containing protein 16 (ZBTB16).

[Angiogenesis] A pharmacological approach using 5-aminolevulinic acid was employed to dysregulate heme/porphyrins homeostasis in endothelial cells.

[JCI Insight] Scientists demonstrated that conditional deletion of Erg in endothelial cells spontaneously alters the aberrant neutrophil (PMN) transcriptome, which is enriched with genes that induce PMN recruitment, adhesion, activation, and 'do not eat me' signals due to impaired synthesis of the deubiquitinase, A20.