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[Nature Aging] Researchers examined how age-associated systemic changes relate to alterations in the local breast tumor microenvironment (TME), with a focus on hormone signaling and inflammation. They identified age-related differences in estrogen disposition and inflammatory profiles that are associated with features of an immunologically altered tumor microenvironment.

[BCRF ] The Breast Cancer Research Foundation (BCRF) announced a $1.5 million grant over five years to support Team ATLAS, an international research collaboration exploring why some people remain breast cancer-free despite age, inherited risk, environmental exposures, or other known risk factors.

[Experimental & Molecular Medicine] The close parallels between mammary stem cells and tumor-initiating cells, particularly their shared plasticity and self-renewal, highlight stemness as a central node linking developmental programs to malignant transformation.

[Cancer Discovery] Investigators described human HER2 HET breast cancer models composed of ERBB2-amplified (HER2hi) and nonamplified (HER2lo) cell populations derived from the same tumor. Utilizing these models, together with cellular barcoding, they demonstrated subclonal cooperation between HER2hi and HER2lo subpopulations.

[Advanced Science] Scientists identified endothelin receptor type A (EDNRA) as a druggable G protein-coupled receptor associated with sustained Hippo/YAP activation and aggressive TNBC phenotypes.

[University of Auckland] Seven research projects offering innovative ideas to achieve better outcomes for a range of health issues including breast cancer, HIV transmission and autoimmune disease have been awarded a total of just over $1 million in the Health Research Council's Explorer grant.

[Nature Communications] Researchers integrated transcriptional regulatory network inference with chromatin accessibility across a large-scale multi-system collection of primary tumors, patient-derived xenografts and model cell lines to quantify transcription factor activity and identify regulators that underpin TNBC identity.

[Science Advances] Researchers showed that the PBRM1 subunit of PBAF is critical for the completion of TGFβ1-mediated epithelial-mesenchymal transition (EMT) of mammary cells in vitro as well as the metastasis of murine breast cancers in vivo.

[Cell Reports Medicine] Investigators presented a biomarker-guided characterization of 40 patient-derived breast cancer organoids, with the aim of modeling resistant disease with greater fidelity and developing an in vitro system grounded in clinical data for testing alternative treatment strategies.

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

[The Den] Mercer University School of Medicine has been awarded the fifth annual Collaborative Cancer Research Seed Grant of $100,000 to advance research aimed at improving treatment for one of the most aggressive forms of endometrial cancer. This grant will support a research project led by Dr. Ilana Chefetz Menaker.

[Queen's Gazette] 13 research teams at Queen’s University have received a combined $12.7 million from the Canadian Institutes of Health Research (CIHR). Awarded through CIHR's Project Grant: Spring 2026 competition, each project will work towards advancing the wellbeing of Canadians through translational research.