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[Leukemia] Scientists uncovered a previously unrecognized role for Deleted in Liver Cancer 1 (Dlc1) in coupling vessel function to hematopoietic cell output, with implications for understanding bone marrow failure syndromes and targeting endothelial dysfunction in hematologic diseases.

[Nature Immunology] The authors summarize the current understanding of how adaptive immunity can shape the progression of neurodegenerative diseases and highlight cross-disease parallels and potentially shared mechanisms.

[Cell Death & Disease] Serpine1 and its protein product Plasminogen Activator-Inhibitor-1 are highly upregulated in endothelial cells after stroke. Researchers hypothesized that inhibiting this pathway within brain endothelial cells could be beneficial for stroke recovery by promoting fibrinolysis and cerebral blood flow.

[Acta Pharmacologica Sinica] Investigators identified poly(ADP-ribose) polymerase 1 (PARP1) as a critical driver of endothelial-to-mesenchymal transition in ischemic heart failure.

[Cancer Research] Scientists evaluated surgically resected pancreatic ductal adenocarcinoma (PDAC) from patients who exercised during neoadjuvant chemotherapy to demonstrate that exercise remodeled PDAC vasculature and improved tumor vascular function in patients.

[Science] Researchers identified a distinct mode of CD4+ T cell–mediated tumor control that induces inflammatory remodeling of the tumor stroma and disrupts tumor vasculature rather than directly killing cancer cells.

[Acta Pharmacologica Sinica] The authors summarize the context-dependent functions of adenosine receptors in vascular conditions with particular emphasis on mechanisms associated with endothelial-mesenchymal transition, vascular inflammation, and metabolic reprogramming.

[Cardiovascular Research] Investigators studied the inflammation-induced emergence of immunomodulatory endothelial cells and characterized their crosstalk with T cells.

[Fluids and Barriers of the CNS] Scientists examine the functional alterations of the blood-brain barrier induced by different CD4+ T cell subsets in ischemic stroke and explore the associated molecular mechanisms.

[Circulation Research] The authors described a critical role of the α2 subunit of glycine receptor (GLRA2) in modulating endothelial nitric oxide synthase signaling and blood pressure regulation.

[Outlook Therapeutics] Outlook Therapeutics, Inc. announced the US FDA has acknowledged receipt of the resubmission of the Biologics License Application for ONS-5010/LYTENAVA™ for the treatment of neovascular age-related macular degeneration (nAMD), or wet AMD.

[4D Molecular Therapeutics] 4D Molecular Therapeutics announced enrollment completion for 4FRONT-2, the second Phase III clinical trial in their global program, evaluating 4D-150 in patients with wet age-related macular degeneration (wet AMD).