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[International Journal of Oral Science] The authors elaborate on the regulatory roles and underlying molecular mechanisms of mechanical signals in key dentofacial developmental processes, including crown development, root morphogenesis, tooth eruption and replacement, as well as maxillomandibular bone development and remodeling.

[RCF] Rutledge Cancer Foundation (RCF) is advancing an ambitious new approach to Ewing sarcoma research through its $1.5 million ACES Grant, a three-year initiative bringing together leading researchers from John Hopkins and National Institutes of Health to pursue new treatment strategies.

[Cell Stem Cell] Scientists presented a stiffness-responsive MSC-assisted relayed tumor-targeting platform that converts matrix stiffness into a programmable molecular entry point for radiotheranostics.

[iScience] Researchers investigated whether sheets derived from hiPSC-derived mesenchymal progenitor cells (MPCs) can survive and form tissue-like structures after xenotransplantation. demonstrate that hiPS-MPC sheets generate vascularized tissues in vivo and support survival across species.

[Journal of Dental Research] Scientists identified intercellular mitochondrial transfer from dental pulp stem cells to endothelial cells as a critical survival and angiogenic mechanism under hypoxic stress.

[Advanced Science] Investigators combined the anti-inflammatory small-molecule rosiglitazone with MSCs to construct a cell–drug conjugate using MSCs as cellular carriers. Rosiglitazone was encapsulated within nanoparticles coated with neutrophil membranes and anchored onto the MSC surface.

[Cell Reports] The authors identified ovarian tumor domain-containing protein 1 (OTUD1) as an RNA-binding protein that controls MSC fate by stabilizing osteogenic transcripts. OTUD1 directly binds and stabilizes bone morphogenetic protein 2 mRNA, thereby supporting osteogenic differentiation.

[Chinese Medical Journal] Researchers performed a comprehensive analysis of MSCs heterogeneity through single-cell transcriptomic mapping across nine human tissue sources and identified the keratin 8 high-expression subpopulation of human umbilical cord-derived MSCs with enhanced functional properties.

[Microbiology Spectrum] Researchers identified a stably integrated and transcriptionally active anellovirus genome in anAML cell line, providing a unique model to study viral persistence in hematopoietic cells.

[Blood Advances] Scientists showed that CD55 protects hematopoietic stem and progenitor cells from complement-mediated damage in aplastic anemia, highlighting complement inhibition as a potential therapeutic strategy

[Nature Communications] Using murine models and human mixed lineage leukemia (MLL)-r leukemia cells, the authors showed that the FA pathway suppresses leukemogenesis by limiting error-prone non-homologous end joining-mediated genomic instability.

[Blood] By screening the nucleoporin (NUP) family, scientists identified NUP214 as a frequently overexpressed gene and a critical fitness determinant in leukemia stem cells (LSCs). NUP214 acts as a conserved driver of LSC survival by restricting heme catabolism, limiting Fe²⁺ accumulation, and suppressing lipid peroxidation.