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[Molecular Cancer] The authors summarize recent advances in CAR-NK cell therapy for hematologic malignancies and outline strategies to enhance its efficacy.

[Leukemia] Researchers generated two types of CD70-targeting CAR-NKT cells. Both CAR70-NKT cell products exhibited potent cytotoxicity against acute myeloid leukemia cells and synergized with hypomethylating agents.

[Science Translational Medicine] Investigators established a clinically translatable erythrocyte-based mRNA platform that enables direct in vivo immune cell programming.

[Journal for Immunotherapy of Cancer] Scientists demonstrated the pleiotropic benefits of IL-12 armored CAR-T cells with improved targeting of antigen-positive tumor cells and simultaneous remodeling of the microenvironment to engage adaptive immunity against antigen-negative clones.

[Cancer Gene Therapy] The authors discuss the potential role of the endogenous T cell receptor as either a hindrance or partner to CAR T cell function.

[Experimental Hematology] Researchers presented a structure-guided humanization strategy for the development of CD22-targeted CAR-T cells to treat relapsed or refractory B cell malignancies.

[Keck School of Medicine of USC] Researchers from the Keck School of Medicine of USC are receiving up to $6.8 million for a two-year research project to develop new computational models and support tools that could accelerate access to cell and gene therapies for children with rare diseases.

[Rubedo Life Sciences, Inc. (Business Wire)] Rubedo Life Sciences, Inc., announced preliminary results from a single-center, ascending-dose, randomized, double-blind, vehicle-controlled trial in patients with plaque psoriasis, atopic dermatitis, and skin aging.

[Cell] Scientists showed that late embryonic full-thickness skin injuries heal by regenerating epithelial, mesenchymal, neuronal, and vascular tissues with proper connectivity.

[Nature Communications] Researchers revealed that keratinocytes and neutrophils are the two major cell types targeted by Tat-PYC-Smad7 to promote diabetic wound healing, providing insight into mechanisms of diabetic wound healing defects targetable by Smad7-based therapy.

[Cell Death & Disease] Scientists identifed mitochondrial DNA release as a pivotal event linking oxidative stress to immune activation in keratinocytes. They demonstrated that hydrogen peroxide induces a sequential mitochondrial membrane remodeling process.

[Cell Death Discovery] Investigators showed that G protein-coupled estrogen receptor 1 (GPER1) signaling is downregulated in lesional skin of psoriasis patients and negatively correlates with both inflammation markers and keratinocyte proliferation.