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[Premier Anesthesia] Premier Anesthesia announced a new partnership with City of Hope^® Phoenix Cancer Center, marking its expansion into the Arizona healthcare market and enhancing its commitment to comprehensive cancer care.

[Signal Transduction and Targeted Therapy] Researchers developed DC551040, an irreversible covalent lysine demethylase 1 (LSD1) inhibitor characterized by high potency, excellent selectivity, and oral availability, which exhibits robust anti-AML effects in vitro and in vivo and is currently progressing through Phase I clinical trials.

[Science Advances] Through a targeted screen of compounds that inhibit key nodes of PRMT5-regulated pathways, investigators identified a synthetic lethality between inhibition of PRMT5 and LSD1, a lysine demethylase known to affect AML blast differentiation.

[Leukemia] Scientists demonstrated that inhibition of the oncogenic kinase BCR::ABL1 in chronic myeloid leukemia cells induces ribosome collisions and activates the ribotoxic stress response.

[Leukemia] Researchers investigated the oncogenic function of protein arginine methyltransferase 1 (PRMT1) and assess the therapeutic efficacy of a selective PRMT1 inhibitor, C7280948, in chronic lymphocytic leukemia.

[Cell Death & Disease] In AML cell lines, scientists identified two distinct, unbalanced isoforms of BCLAF1: the full-length isoform, which exhibits oncogenic properties, and the short-length isoform, which seems to act as a tumor suppressor.

[Cell Death Discovery] The authors assessed the molecular mechanisms of autophagy inhibition associated with FLT3 inhibitors and its impact on cell survival and pharmacological resistance.

[Experimental Hematology] Investigators developed hematopoietic stem cell-targeted lipid nanoparticles by integrating Bayesian optimization with our functional amino lipids.

[Blood] Investigators established that NUTM1-rearranged leukemia is a discrete entity characterized by a unique transcriptional and epigenetic landscape, notably featuring global DNA hypomethylation, irrespective of the 5′ fusion partner.

[Nature Reviews Genetics] Scientists examine studies of rare and common germline and somatic variation affecting haematopoiesis, highlighting fundamental principles that emerge.

[Molecular Cancer] The authors summarize recent advances in CAR-NK cell therapy for hematologic malignancies and outline strategies to enhance its efficacy.

[Leukemia] Researchers generated two types of CD70-targeting CAR-NKT cells. Both CAR70-NKT cell products exhibited potent cytotoxicity against acute myeloid leukemia cells and synergized with hypomethylating agents.