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[Nature] Using integrated single-cell, spatial, and functional analyses, scientists defined the earliest multicellular events that license this transition following oncogenic activation in the lung.

[Circulation] The functional role of SIRT5 in cardiac fibrosis was evaluated through cardiac fibroblast-specific knockout and overexpression of Sirt5 in mice.

[Experimental & Molecular Medicine] Researchers investigated the role and targetability of vascular adhesion protein 1 (VAP1) in cardiac fibrosis.

[Advanced Healthcare Materials] Investigators presented REFRESH—Reversible Embedded Bioprinting for Faster Reinforcement and Structuring of dECM Hydrogels, a next-generation embedded bioprinting platform designed for high-fidelity fabrication of anatomically relevant tissue constructs using dECM hydrogels.

[Biofabrication] Scientists investigated the printability of medical-grade poly(L-lactide-co-caprolactone) (PLCL), which has a faster degradation rate, resulting in melt electrowriting PLCL scaffolds characterized by uniform fiber diameter, regular layer stacking, and customizable pore sizes.

[Nanoscale] Researchers developed a nanoplatform using gold nanodandelions (GNDs@gelatin) as a nanoradioenhancer, loaded with 6-diazo-5-oxo-L-norleucine (DON), to form matrix metalloproteinase-triggered dual-functional RT/metabolic reprogramming nanoplatform, termed GNDs@gelatin/DON.

[Nature Cancer] The authors review the current understanding of cancer-associated fibroblasts as heterogeneous, instructive regulators of tumor microenvironments across anatomic sites and highlight key challenges for the future.

[XORTX Therapeutics, Inc.] XORTX Therapeutics, Inc. announced the closing of the acquisition of the Vectus kidney anti-fibrotic asset.

[The Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) announces the first recipients of its LCRF Team Science Award on Advancing Therapies Toward Curing EGFR Mutated Lung Cancers.

[Nature Communications] Scientists demonstrated that genetic depletion of Ubiquitin Specific Peptidase 30, a negative regulator of mitophagy, boosts mitophagy and restores mitochondrial function in AT2 cells, leading to protection from injury-induced apoptosis and enhanced stem cell activity.

[Journal of Translational Medicine] MRC-5 cells and mouse primary lung fibroblasts treated with TGF-β1 combined with Vitamin D were used to explore the role of vitamin D on fibroblast activation and glycolysis in vitro.

[Nature Communications] Investigators showed that ELMO2 represents a specific vulnerability in mesenchymal-like cells. ELMO2 suppression induces excessive autophagy and cell death via FAK activity inhibition.