PCBP1 Regulates the Transcription and Alternative Splicing of Metastasis-Related Genes and Pathways in Hepatocellular Carcinoma

Researchers obtained and analyzed PCBP1-knockdown RNA-seq data and eCLIP-seq data of PCBP1 in HepG2 cells and found that PCBP1 widely regulated the alternative splicing and expression of genes enriched in cancer-related pathways, including extracellular matrix, cell adhesion, small molecule metabolic process and apoptosis.