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[Nature Communications] Researchers showed that the X-linked histone demethylase 6 A (KDM6A) is essential for maintaining healthy cholesterol metabolism in the liver.

[Journal for Immunotherapy of Cancer] Investigators offered a novel strategy to enhance HCC immunotherapy by blocking nuclear factor erythroid 2-related factor 2 (Nrf2), which has the potential to address the low response rates observed with current HCC immunotherapies.

[BMC Medicine] Scientists investigated whether pharmacologic inhibition of MST3 could attenuate the initiation and progression of metabolic dysfunction-associated steatohepatitis-associated HCC in vivo.

[Cell Death & Disease] The authors identify T cell intracellular antigen 1 (TIA1) as a crucial hepatoprotective factor that attenuates metabolic dysfunction-associated steatotic liver disease progression by orchestrating stress granule-dependent translational control of Srebf1 mRNA.

[Alimentary Pharmacology & Therapeutics] Researchers identified independent risk factors of HCC after hepatitis B surface antigen seroclearance and developed and validated a risk prediction model.

[Journal of Ethnopharmacology] Scientists validated the molecular mechanism of albiflorin ALB against liver fibrosis, integrating both in vivo and in vitro experiments with molecular docking and molecular dynamics simulations.

[Journal of Ethnopharmacology] Investigators provided compelling evidence supporting the potential application of CSP-W for managing chronic liver fibrosis.

[Expert Opinion on Drug Metabolism & Toxicology] Hepatocyte-like cells generated from monocytes of iDILI patients are being developed as an ex vivo assay to enhance understanding of underlying molecular mechanisms and to assist in drug causality assessment, especially in cases involving multiple agents.

[Gyre Therapeutics, Inc.] Gyre Therapeutics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted priority review status to the New Drug Application for Hydronidone as a treatment for chronic hepatitis B-induced liver fibrosis, which is liver damage resulting from the infection of the hepatitis B virus.

[Autophagy] Using single-cell RNA sequencing, researchers identified SFRP2 as a critical mediator of profibrotic myofibroblasts in idiopathic pulmonary fibrosis lungs.

[Molecular Oncology] Investigators identified the transcription factor E2A as a critical mediator of resistance to transforming growth factor-β (TGF-β)-induced apoptosis in mutant KRAS–driven NSCLC.

[Molecular Cancer Therapeutics] Researchers used patient-derived xenografts to model small cell lung cancer chemoradiation resistance and identified chemoradiation resistance candidate genes using RNA sequencing.