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[Cell Stem Cell] Researchers established Cardiopedia-Ligand, a comprehensive perturbation-function-transcriptome atlas generated by stimulating human cardiac organoids with 87 ligands targeting 98 cell-membrane receptors expressed in the human heart.

[Emerging Microbes & Infections] Investigators established long-term expanding three-dimensional porcine airway organoids as a platform for the phenotypic and transcriptomic characterization of reassortant influenza viruses.

[Science Advances] Scientists developed vascularized liver organoids by integrating hiPSC–derived hepatoblasts and endothelial cells into decellularized scaffolds functionalized with an anti-CD31 aptamer–based vascular coating agent.

[Science Advances] In this study, patient tumor organoids were generated from 35 tumors of pancreatic, small intestinal, and gastric origin, obtained from 17 patients.

[Oncogene] The authors established a total of 30 patient-derived organoids from 79 patients with locally advanced and recurrent/metastatic head and neck squamous cell carcinoma.

[Journal of Cell Science] Researchers aimed to evaluate the effects of MutS Homolog 2 (Msh2) loss on stem cell functions, including differentiation, clonogenicity, and proliferation, in murine esophageal organoids.

[AcroCyte Therapeutics, Inc.] AcroCyte Therapeutics, Inc. announced that it has been selected to receive funding from the Advanced Research Projects Agency for Health (ARPA‑H) to advance scalable human organoid technologies for regenerative medicine applications.

[Nature Aging] Researchers examined how age-associated systemic changes relate to alterations in the local breast tumor microenvironment (TME), with a focus on hormone signaling and inflammation. They identified age-related differences in estrogen disposition and inflammatory profiles that are associated with features of an immunologically altered tumor microenvironment.

[BCRF ] The Breast Cancer Research Foundation (BCRF) announced a $1.5 million grant over five years to support Team ATLAS, an international research collaboration exploring why some people remain breast cancer-free despite age, inherited risk, environmental exposures, or other known risk factors.

[Experimental & Molecular Medicine] The close parallels between mammary stem cells and tumor-initiating cells, particularly their shared plasticity and self-renewal, highlight stemness as a central node linking developmental programs to malignant transformation.

[Cancer Discovery] Investigators described human HER2 HET breast cancer models composed of ERBB2-amplified (HER2hi) and nonamplified (HER2lo) cell populations derived from the same tumor. Utilizing these models, together with cellular barcoding, they demonstrated subclonal cooperation between HER2hi and HER2lo subpopulations.

[Advanced Science] Scientists identified endothelin receptor type A (EDNRA) as a druggable G protein-coupled receptor associated with sustained Hippo/YAP activation and aggressive TNBC phenotypes.