Notch1 Activation of Jagged1 Contributes to Differentiation of Mesenchymal Stem Cells into Endothelial Cells under Cigarette Smoke Extract Exposure

In vitro, Jagged1 was found to be activated by Notch1 in MSCs, resulting in the RBP-Jκ-dependent expression of Jagged1 mRNA, a response that was blocked by Notch1 inhibition.