Newsletters

[Cell Stem Cell] Investigators demonstrated that methyltransferase-like 3 deficiency reverts naive hESCs to a totipotent-like state with reactivation and chromatin resetting of 8C-associated genes, eRNAs, and long terminal repeats (LTRs).

[Current Cardiology Reports] The authors provide an overview of hiPSC-derived cardiovascular lineages and describe their impact on drug testing in vitro.

[Scripps Research] Scripps Research associate professor Giordano Lippi has been awarded a $4 million grant from the California Institute for Regenerative Medicine (CIRM) to develop a novel platform that could restore healthy gene function in neurodevelopmental disorders caused by haploinsufficiency.

[npj Precision Oncology] Functional assays demonstrated that MYSM1 promotes LUAD cell proliferation and migration in vitro and in vivo.

[British Journal of Cancer] Investigators reported that hepatic leukemia factor (HLF) acts as a tumor-suppressor gene in intrahepatic cholangiocarcinoma (ICC) and B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) represses HLF to drive ICC initiation and progression.

[Nature Reviews Chemistry] The authors outline small-molecule-based control approaches of CAR-T cells, categorizing them by function and detailing their molecular mechanisms.

[elife] Investigators identified transcriptomic differences at the single-cell level, between astrocytes generated from LMX1A reporter positive or negative cells, as well as non-patterned astrocytes and neurons.

[Journal of Neuroscience] Using mice of both sexes, researchers performed RNA-sequencing on the hippocampal dentate gyrus and identified differentially-expressed regulators of neurogenesis in the Wnt signaling pathway that regulates many aspects of cell proliferation.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Using cells isolated from pleural fluid and diagnostic pleural biopsy, scientists generated pleural mesothelioma patient-derived organoids and reactive-mesothelial-patient derived organoids.

[Stem Cell Research & Therapy] Investigators employed retinal organoids derived from a VSX2-enhanced green fluorescent protein reporter hiPSC line for positive selection of human retinal progenitor cells, investigated their features, and facilitated their applications.

[Journal of Experimental & Clinical Cancer Research] Scientists established a neuroendocrine prostate cancer mouse allograft model and performed RNA sequencing to identify genes associated with cisplatin resistance.

[Gut] Researchers identified a critical subpopulation of cancer-associated fibroblasts in promoting an immunosuppressive tumor microenvironment and enabling immune evasion, which may influence the therapeutic effectiveness of immune checkpoint inhibitors for gastic cancer.