Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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LINC01198 Activates Hippo Signaling to Stimulate IL-1β Autocrine for Driving Vemurafenib Resistance by Associating with TAOK1/2 in Melanoma

October 30, 2025

[Cell Death Discovery] Scientists established vemurafenib-resistance melanoma cell strain together with acute vemurafenib treatment and characterized LINC01198 as the only one LncRNA up-regulated in both of stable vemurafenib-resistant and acute vemurafenib-treated melanoma cells.

Molecular Glue Degrader Function of SPOP Enhances STING-Dependent Immunotherapy Efficacy in Melanoma Models

October 30, 2025

[Journal of Clinical Investigation] Scientists revealed that SPOP targeted the innate immune sensor STING for degradation in a CK1γ phosphorylation-dependent manner to promote melanoma growth.

Subclinical Fields of BRAF V600E-Mutant Melanocytes Populate Human Skin and Are Enriched Around Melanoma and Naevi

October 30, 2025

[British Journal of Dermatology] The authors identified BRAF V600E-mutant melanocytes in skin surrounding naevi and primary melanomas, even years after tumour excision. Fields

Insight Into the Cellular Activities of Tranexamic Acid As an Option for Melasma Treatment

October 30, 2025

[Cell Biology International] Scientists investigated tranexamic acid's (TXA) impact on melanocytes, keratinocytes, and inflammatory cells. TXA directly inhibits melanin synthesis in B16 melanoma cells, with an additive effect when combined with α-arbutin.

In Long-Lasting Cellular Stress Phases of Melanoma Cells, Stress Granules Are Dissolved by HSP7

October 30, 2025

[Cellular and Molecular Life Sciences] Researchers demonstrated that melanoma cells express high endogenous levels of HSP70, which preserves protein homeostasis and inhibits apoptosis under both environmental and drug-induced stress.

Regulation of Melanin Synthesis in Goat Hair Follicles by Melatonin through the Wnt/β-Catenin Pathway

October 28, 2025

[Molecular Genetics and Genomics] Scientists revealed that melatonin can reduce melanocyte viability, inhibit proliferation, promote apoptosis, reduce melanogenesis, and affect melanin synthesis through the Wnt/β-catenin signaling pathway.

RIPK3 Promotes Skin Inflammation by Enhancing IL-36α Signaling and Necroptosis in Keratinocytes

October 28, 2025

[Cell Death & Disease] The authors demonstrated that receptor-interacting protein kinase 3 (RIPK3) expression was significantly upregulated in psoriasis patients and mice with imiquimod-induced skin inflammation

Genistein Enhances Anti-PD-1 Efficacy in Melanoma by Suppressing Regulatory T Cell Differentiation and Activity

October 22, 2025

[Scientific Reports] Researchers investigated the synergistic efficacy of genistein with anti-PD-1 therapy in a mouse model of melanoma.

CD271 Orchestrates Skin Structure, Differentiation, and Inflammation via PI3K/Akt and PKCα/ERK Pathways

October 22, 2025

[Cell Death & Disease] Researchers developed and characterized two novel mouse models, the CD271cKO and the CD271ciKO, where CD271 is conditionally absent in keratinocytes during development or after topical induction, respectively.

And-1 Coordinates with Polymerase δ to Regulate Nucleotide Excision Repair and UVB-Induced Skin Tumorigenesis

October 22, 2025

[Nature Communications] The authors identified a critical role of And-1 in the nucleotide excision repair pathway. Specifically, And-1 accumulates at UV lesion sites in cells upon exposure to UVB. Inhibition of And-1 in human cells compromises the repair of photoproducts in DNA and reduces cell viability following UVB exposure

The Dark Side of the Light (UVA): Melanoma Microenvironment and Cell Survival Strategies

October 20, 2025

[Nature Communications] Scientists reported for the first time that UVA induces global DNA methylation as a compensatory mechanism in response to UVA-induced DNA Damage in melanoma and melanocyte cells.

Acidic Melanoma Microenvironment Selects for a Senescence-Like but Also Migratory-Active Subpopulation Driving Metastatic Disease

October 20, 2025

[Cell Death Discovery] Researchers demonstrated that the acidic tumor microenvironment drives tumor plasticity in melanoma and results in the formation of a small subpopulation, which promotes metastasis.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.