Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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Hydrogel-Extracellular Vesicle Engineering Delivery System: A Promising Therapeutic Strategy for Wound Healing

March 16, 2026

[Journal of Nanobiotechnology] Investigators systematically synthesizes contemporary advances in extracellular vesicles hydrogel systems for chronic wound therapy.

US FDA Approves Bristol Myers Squibb’s Sotyktu® (deucravacitinib) for the Treatment of Adults with Active Psoriatic Arthritis

March 16, 2026

[Bristol Myers Squibb (Business Wire)] Bristol Myers Squibb announced that the US FDA has approved Sotyktu^® (deucravacitinib) for the treatment of adults with active psoriatic arthritis.

Psoriasis-Like Disease Prevents Squamous Skin Tumor Development by Neutrophil-Driven Inflammation

March 13, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Using cell transplantation and chemical-induced models of cutaneous squamous cell carcinoma combined with inducible genetically engineered mouse models of psoriasis, scientists investigated how chronic skin and systemic inflammation affects squamous skin tumor initiation and progression.

Cortistatin Antagonizes Piezo1-STING Axis and Facilitates Mitochondrial Homeostasis of Keratinocytes by Attenuating AGEs Accumulation in Diabetic Ulcers

March 13, 2026

[Cell Death & Differentiation] Researchers demonstrated that mechanical stress induces glucose accumulation and downstream metabolic stress in keratinocytes.

Staphylococcus Aureus Augments Epithelial Skin Barrier Damage through T Cell Activation in Cutaneous T Cell Lymphoma

March 13, 2026

[Allergy] Scientists investigated how the interplay between S. aureus (and staphylococcal enterotoxins) and primary malignant- and non-malignant T cells affects keratinocyte expression of skin barrier proteins.

The Impact of ERAP1 Inhibition on Metabolite Homeostasis of Melanoma Cells

March 13, 2026

[Scientific Reports] The authors treated a melanoma cancer cell line with near saturating doses of an allosteric ERAP1 inhibitor and compared metabolite homeostasis to untreated and knock-out cells.

C1s Protects Cutaneous Squamous Carcinoma Cells from TRAIL-Induced Apoptosis

March 13, 2026

[Oncogenesis] Scientists investigated the mechanistic role of C1s in regulating apoptosis by examining its impact on cell surface proteome of cutaneous squamous cell carcinoma cells.

Discovery of an ITK and TRK Kinase Inhibitor for the Potential Topical Treatment of Atopic Dermatitis

March 13, 2026

[Nature Communications] Scientists described PF-07245303, a compound which potently inhibits IL-2-inducible T cell kinase and tropomyosin-related kinase family kinases capable of inhibiting T cell receptor-mediated cytokine production from CD4 and CD8 T cells and suppressing nerve growth factor-induced human basophil activation.

Mfsd2a Is Important for Maintaining Epidermal Homeostasis

March 2, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Investigators utilized mouse models of epidermal Mfsd2a deficiency, histological and gene expression analysis, untargeted lipidomics, and human keratinocyte cultures, demonstrating that the epidermal keratinocytes acquire plasma-derived LPC via Mfsd2a mediated transport.

Inhibition of Keratinocyte Necroptosis Mediated by RIPK1/RIPK3/MLKL Provides a Protective Effect against Psoriatic Inflammation

March 2, 2026

[Cell Death & Disease] Scientists provided evidence for the involvement of necroptosis in psoriasis. Receptor interacting protein kinase 1 (RIPK1) and mixed lineage kinase domain-like pseudokinase (MLKL) were significantly upregulated and localized in all layers of the epidermis in human psoriatic lesions, while RIPK3 and phosphorylated MLKL were mainly expressed in keratinocytes, which were located in the upper layers.

A Mechanically Tunable Photo-Cured Hydrogel System Based on Methacrylated Collagen-Keratin Inter-Penetrating Networks for Rapid and Enhanced Wound Healing

March 2, 2026

[International Journal of Biological Macromolecules] Researchers developed injectable photo-cured methacrylated collagen-keratin interpenetrating network hydrogels for rapid enhanced wound healing.

Fufang Baizhi Tincture Protects Melanocytes from Oxidative Stress by Targeting CASP7-Mediated Apoptosis and EP300-Associated Transcriptional Regulation

March 2, 2026

[Journal of Ethnopharmacology] Investigators elucidated the potential mechanism of a traditional therapy for vitiligo and identified CASP7 and EP300 as potential key targets. Fufang Baizhi Tincture likely exerts its protective effects by modulating these targets to regulate melanocyte apoptosis and transcription, providing a robust scientific basis for its clinical application.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.