[Cell Reports] Researchers demonstrated the therapeutic potential of disrupting interactions between the androgen receptor and its coregulator WDR77. WDR77 stimulates prostate cancer growth, and its overexpression was associated with worse patient survival.

[Medical Oncology] The authors present a novel, mechanism-centered synthesis focused specifically on miRNA-mediated resistance pathways across standard treatment modalities, including androgen deprivation therapy, enzalutamide, docetaxel, and radiotherapy.

[Nature] Scientists reported human gastroids, a self-organized multilineage gastric organoid derived from hPSCs to model gastric fundic-antral patterning in vitro.

[Advanced Healthcare Materials] The authors highlight the latest advancements and current limitations in targeted drug delivery strategies for the lower gastrointestinal tract, aiming to improve therapeutic outcomes and the quality of life for patients with intestinal disorders.

[Molecular Diagnosis & Therapy] Scientists explore the application of gastric cancer-derived organoids in preclinical research and clinical translation, highlighting current challenges and outlining future prospects.

[Gut] Investigators demonstrated that fructose plays a dual role in promoting colorectal cancer progression by influencing both tumour cells and cancer associated fibroblasts.

[EMBO Molecular Medicine] Scientists reported that TET3 depletion in cultured cardiac fibroblasts blocked transition to myofibroblasts in response to different pro-fibrogenic stimuli.

[Science Advances] Scientists identified that the talin interacting proteins deleted in liver cancer 1 (DLC1), Rap1-interacting adaptor molecule, and paxillin each preferentially bind to talin at a specific ECM stiffness.

[Advanced Science] Through comprehensive single-cell transcriptomic profiling of enzalutamide (ENZ)-naïve and ENZ-treated tumors, an expansion of ENZ-resistant myofibroblastic cancer-associated fibroblast was identified that correlates with adverse clinical outcomes.

[Cancer Research] While shed TROP2 extracellular domain did not affect prostate cancer cell proliferation and tumor growth, it increased cell migration and invasion in vitro and promoted metastatic colonization and spontaneous metastasis in vivo.

[Journal of Experimental Medicine] Researchers employed multilayered single-cell analytic approaches including chromatin, gene, and protein profiling to characterize a unique CD4⁺ T_RM subset present in the inflamed gut mucosa of Crohn’s disease patients.

[Advanced Science] Combining molecular docking, SPR analysis, and Biotin-pulldown analysis, researchers demonstrated that serine/threonine kinase 33 can bind Bufalin, a key active ingredient of the traditional Chinese medicine HuaChansu.