[Daiichi Sankyo] The European Medicines Agency has validated the Type II Variation marketing authorization application for ENHERTU^® (trastuzumab deruxtecan) in combination with pertuzumab for the first-line treatment of adult patients with unresectable or metastatic HER2 positive breast cancer.

[Nature Communications] Investigators revealed a critical role for UFMylation in lipid metabolism and identify the UFL1-AKT axis as a potential therapeutic target in breast cancer.

[Science Advances] Scientists presented a crotonate–crotonyl–coenzyme A–enhancer of zeste homolog 2 (EZH2) crotonylation cascade blocking breast cancer growth and metastasis.

[Cancer Research] Investigators showed that following chemotherapy, diverse therapeutic agents converge on WNT pathway activation to induce a de novo diapause-like cell state across various TNBC line, xenograft, and patient-derived organoid models.

[Cell Death & Disease] Researchers revealed a forward feedback loop between Ubiquitin Specific Peptidase 8 (USP8) and Hippo signaling in TNBC, indicating USP8 as a potential therapeutic drug targets in TNBC.

[Journal of Medicinal Chemistry] The authors identified new pre-microRNA-210 (miR-210) ligands, which exhibited a submicromolar affinity for the miR-210 precursor and potently inhibited its maturation in vitro.

[Biomaterials Science] Researchers developed a pH-responsive nanoparticle-to-hydrogel system for long-lasting retention of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors at the tumour site and promoting apoptosis in TRAIL-sensitive TNBC cells.

[Journal of Proteomics] Scientists investigated the antitumor potential of two novel dinuclear Cu²-complexes, [Cu₂(μ-CH₃COO)(L)(OH₂)]·2H₂O and [Cu₂(μ-OH)(HL)(OH₂)]ClO₄·2H₂O, in MCF-7 breast cancer cells.

[Molecular and Cellular Biochemistry] The authors explored the function and potential regulatory mechanisms of SLC31A1 in breast cancer. SLC31A1 expression was significantly elevated in breast cancer tissues, and high expression was associated with poor prognosis.

[Journal of the Egyptian National Cancer Institute] Scientists investigated CaSR gene expression levels, its correlation with oncogenic pathways, and its protein localization in human breast cancer tissues.

[British Journal of Pharmacology] Investigators synthesize the available evidence on the role of the opioid system in breast cancer, with particular emphasis on molecular mechanisms of receptor signalling, their interactions within the tumour microenvironment, and the clinical implications for pain management.

[Neuron] Researchers utilized single-cell and spatial transcriptomics from primary and recurrent glioblastoma (GBM) tumors, immunohistochemistry, cytokine profiling, and migration assays to show that GBM cells recruit oligodendrocytes to the tumor border via fractalkine signaling.