[Cell Death & Disease] Researchers silenced progesterone receptor expression in the luminal breast cancer cell lines, MCF7 and T47D, which led to accelerated proliferation and pentose phosphate pathway activity with G6PD expression.

[Breast Cancer Research] Scientists revealed that PAK2 promotes circulating tumor cell cluster formation and breast cancer metastasis by enhancing E-cadherin-mediated cell-cell adhesion.

[Scientific Reports] Investigators reported that over 70% of TNBC cells express cell surface GRP78 (csGRP78). MDA-MB-231 cells predominantly exhibit a distinct unipolar morphology, with csGRP78 prominently co-localizing with the variant isoform of CD44.

[Cell Death & Disease] Scientists highlighted that the secreted phospholipase A2 human group IIA (contributes to prostaste cancer pathology primarily through specific protein-protein interactions.

[Cell Death & Disease] Investigators showed that a high salt diet inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung.

[Cell Death & Disease] The authors characterized LINC00520 (LENT) regulated by microphthalmia-associated transcription factor and strongly expressed in melanocytic melanoma cells. LENT is essential for the proliferation and survival of cultured melanocytic melanoma cells and xenograft tumors.

[Journal for Immunotherapy of Cancer] Scientists revealed the molecular mechanism underlying etoposide-activated CD8+ T cell anti-tumor immunity. The combination of etoposide and anti-PD-1 antibody has the potential to benefit patients with advanced osteosarcoma.

[Diabetologia] The authors determined the number, density and islet-protective phenotype of pancreatic MSCs in situ in individuals with and without type 1 diabetes.

[Molecular Cancer] The authors discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.

[Immunology] Scientists highlight the critical roles of STAT1, STAT3, STAT5 and HIF1α in regulating mucosal-Associated Invariant T (MAIT) cell effector functions.

[Allergy] Scientists highlight the distinct roles of IFN-α and IFN-γ in modulating an immune response against abacavir (APC), with IFN-γ increasing APC activity and IFN-α impairing Treg-mediated regulation in immune competent mice.

[NPJ Parkinson'S Disease] Researchers designed LRRK2-P1446L mutant mice and demonstrated that the novel LRRK2-P1446L mutation drives neurodegeneration through death-associated protein kinase 1 (DAPK1) dysregulation.