[Circulation] Scientists addressed the urgent need to explore the pathologic mechanism of hypothyroidism-induced heart failure in detail and to discover and develop drugs that can target and manage heart failure in patients with hypothyroidism.

[Experimental & Molecular Medicine] Investigators explored the possibility of using stem-cell-derived cardiomyocytes as a source of mitochondrial transplantation to treat Barth syndrome.

[Science Advances] Scientists observed that the deubiquitinating enzyme YOD1 was moderately elevated in human hypertrophic myocardium and mouse models. Cardiomyocyte-specific knockout of YOD1 reduced Ang II– and TAC-induced cardiac hypertrophy.

[Metabolism Clinical and Experimental] Potential causative genetic factors in skeletal muscle and blood causally associated with type 2 diabetes mellitus were identified by Summary-data-based Mendelian randomization analysis.

[Journal of Molecular and Cellular Cardiology] Researchers generated smooth muscle-specific human antigen R (HuR) knockout mice to investigate the function of HuR in vascular calcification.

[European Journal of Pharmacology] Researchers found that EDIL3 levels were elevated in patients with idiopathic pulmonary arterial hypertension, as well as in hypoxia-treated pulmonary artery smooth muscle cells compared to normoxia-treated controls.

[Rejuvenation Research] The authors explore some of the recent discoveries of how misregulation of intrinsic and extrinsic mechanisms drives the decline of muscle stem cell (MuSC) function in aging muscles, and we discuss new strategies to rejuvenate aged MuSC function for regenerative medicine.

[HeartBeat.bio (Biotech Newswire)] HeartBeat.bio AG and biotx.ai GmbH announced a strategic partnership to identify and validate novel therapeutic targets in heart failure. The collaboration combines biotx.ai’s causal mapping of the genome for target discovery with HeartBeat.bio’s human-based Cardioid Drug Discovery Platform to drive innovation in heart failure drug development.

[Nature Communications] Researchers introduced an optimized method that employs mammalian target of rapamycin (mTOR) signaling inhibition in embryonic epicardium, inducing a quiescent state that enhances multi-step epicardial maturation.

[Nature Communications] By integrating multi-omics data across ESC states, scientists identified super-enhancers (SE) interacting with master transcription factors, exemplified by the Klf5-adjacent SE (K5aSE). K5aSE deletion impaired proliferation, differentiation, and Klf5 expression, partially rescued by KLF5 reintroduction.

[Nature Communications] Researchers showed with male mice that hepatic glutamate accumulates in vesicles of perivenous hepatocytes through vesicular glutamate transporter 3 (VGLUT3), regulated by the aryl hydrocarbon receptor upon chronic alcohol intake.

[Nature Communications] Investigators conducted the Phase II LIVERTI trial testing domvanalimab, a monoclonal Fc-silent anti-TIGIT antibody, plus zimberelimab, an anti-PD-1 antibody, in immunotherapy refractory HCC.