[PLoS Pathogens] Researchers showed that reduced expression of Regnase-1, an RNase that negatively regulates immune cell activation, confers resistance to infection with the mouse-adapted SARS-CoV-2 MA10 strain.

[Oncogene] Investigators demonstrate that combining a naturally isolated Senecavirus A strain with the STING agonist MSA-2 supports synergistic type I interferon activation across multiple tumor models.

[Nature Communications] Scientists identified suppression of innate immune responses, especially downregulated Toll-like receptor/NF-kappa B pathways in macrophages/dendritic cells and elevated B/T cell negative regulation, contributing to treatment failure and recurrence.

[PLoS Pathogens] The authors demonstrated that the ability of anti-viral B cell receptors to mediate viral fusion/entry is not universal but depends on the specific viral envelope protein.

[Nature Communications] Researchers showed that H3N2 viruses can use MHCII as an alternative entry receptor in a host-specific manner, and adaptation of human viruses to pigs increases affinity for the MHCII swine leukocyte antigen.

[DZIF] Ethris GmbH and the German Center for Infection Research (DZIF) announced a strategic research collaboration to develop mRNA-based vaccines for the prevention and treatment of infectious diseases.

[Immunity & Ageing] The authors consolidate current knowledge and fill gaps in our understanding of the aged immune response to respiratory viruses.

[Autophagy] Scientists reported that, when neuraminidase (NEU) antigen was redirected into phagophores and subsequently autophagosomes by fusing with microtubule associated protein 1 light chain 3 beta/NEU-LC3B, it could efficiently activate the autophagosome-lysosome-MHC II compartment pathway, and thus substantially improve the magnitude, breadth, and polyfunctionality of NEU-specific T cell immunity in mice.

[Kincell Bio] Kincell Bio announced a new collaboration with RegCell, a biotechnology company developing first‑in‑class immune tolerance platform based on epigenetically reprogrammed regulatory T cells.

[Cell Research] Using long-term live-cell imaging to follow the fates of single ESCs, scientists showed that ESC lineage renewal is achieved through sporadic entry into a state characterized by the expression of two-cell embryo-specific markers.

[Genome Research] Investigators systematically studied microRNA alternative functions in mouse embryonic stem cells by genetically deleting Drosha, leading to global loss of microRNAs.

[EMBO Reports] Scientists showed that NANOG partners with TBX3 and the PRC2 complex to maintain ESC identity by silencing primitive endoderm genes through newly identified distal enhancers.