[Nature] Researchers uncovered a previously unrecognized regulatory axis by which cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A.

[Science Translational Medicine] Investigators found that the developmental transcription factor sine oculis homeobox 1 (Six1) was increased in patients with pulmonary hypertension (PH) and that deleting Six1 in endothelial cells improved pathology in a mouse model of PH.

[Nature Communications] Scientists demonstrated that tumor endothelial cells (TECs) highly express actin-binding genes, with PDZ and LIM domain 5 (PDLIM5), a cytoskeletal protein, significantly upregulated in TECs and correlated with poor patient survival.

[Developmental Cell] Through predictive computational modeling validated in mice, zebrafish, and human cell lines, researchers uncovered that Bmp9 enhances Notch activity synergistically by upregulating Lunatic Fringe in endothelial cells.

[Cell Death & Disease] Scientists investigated the impact of chronic exposure to combined ultra-violet light and the oxidized estrogen metabolite 4-hydroxyestradiol on healthy corneal endothelial cells.

[Stem Cell Research & Therapy] Investigators explored whether endothelial cell (EC)-derived apoptotic extracellular vesicles can promote the differentiation of endothelial progenitor cells into ECs, facilitating wound angiogenesis, and to deeply analyze the underlying molecular mechanisms and key signaling pathways.

[Cell Adhesion & Migration] The authors investigated the effect of UNC5C-AS1 on HUVEC function in preeclampsia (PE). UNC5C-AS1 was downregulated in PE placentas.

[Journal of Clinical Investigation] Using a lymphatic system–specific reporter line, investigators discovered that lymphatic vessels grow toward the nail region from the ventral side of the digit during quiescence and after amputation.

[Nature Reviews Drug Discovery] Scientists consider the blood–brain barrier as a therapeutic target and discuss approaches to its repair and protection in specific disease states and during normal aging.

[4D Molecular Therapeutics] 4D Molecular Therapeutics announced enrollment completion for 4FRONT-1, the first Phase III clinical trial evaluating 4D-150 in patients with wet age-related macular degeneration (wet AMD).

[iScience] Treatment of activated human CD8+ T cells from healthy donors with recombinant PCSK9 reduces surface LDL receptors and ICAM-1 expression, granzyme B secretion, and proliferation.

[Science Immunology] Researchers characterized γδ T cells in intestinal biopsies obtained from patients with ulcerative colitis and healthy donors using single-cell RNA sequencing, T cell receptor profiling, and mass cytometry.