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MEDIPOST Inc. Announces $140 Million in Funding to Accelerate Late-Stage Clinical Development
MEDIPOST, Inc. announced that its parent company, MEDIPOST Co., Ltd., has closed on $140 million in funding. The investment will accelerate the company’s Phase...
Cell Surface Engineering with a Pseudofibrotic ECM Reprograms the Antifibrotic Activity of Mesenchymal Stromal Cells
[Science Advances] Investigators presented a cell surface engineering strategy that reprograms the antifibrotic function of MSCs by constructing a pseudofibrotic extracellular matrix on their surface.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression
[Cancer Research] Scientists investigated the contribution of WT1+ mesenchymal cells to cancer-associated fibroblast populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer.
Effects of Local Anesthetics on Yield and Differentiation of Synovial Mesenchymal Stem Cells
[Scientific Reports] Scientists investigated whether clinically relevant concentrations of lidocaine and ropivacaine affect synovial MSC proliferation and differentiation.
Physical Differentiation of Adipose-Derived Mesenchymal Stem Cells Into Pancreatic Beta-Like Cells Using Cell-Imprinting and Evaluation of Insulin Production
[Adipocyte] Researchers physically induced the differentiation of rat adipose-derived mesenchymal stem cells into β-like cells using the cell-imprinting technique.
Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis
[Tissue Engineering and Regenerative Medicine] Umbilical cord mesenchymal stem cells were used to treat cirrhosis, ranging from end-stage to early stages, in methionine-deficient rats by modulating the Wnt pathway.
Exosomal Mir-451a Derived from Bone Marrow Mesenchymal Stem Cells Inhibits Macrophage M1 Polarization through the MIF/CD74 Signaling Pathway to Alleviate Acute Lung Injury
[Immunological Investigations] Researchers investigated the role of bone marrow MSC-Exos in acute lung injury through the regulation of macrophage polarization.
Therapeutic Efficacy of Mesenchymal Stem Cells (MSCs) on Alzheimer’S Disease: Review of Clinical Results
[Tissue Engineering and Regenerative Medicine] Investigators evaluate the therapeutic effects of MSCs on Alzheimer's disease patients through a review of clinical trial literature.
The Aryl Hydrocarbon Receptor: Structure, Signaling, Physiology, and Pathology
[Signal Transduction and Targeted Therapy] The authors review the involvement of aryl hydrocarbon receptor in pathologies such as cancer and autoimmune and inflammatory diseases and its potential as a therapeutic target.
TRIP13 Promotes the Expansion and Immunosuppression of CD4Foxp3 Regulatory T Cells by Sustaining HAT1 Stability
[Cell Death & Disease] Using RNA-seq profiling of TNFR2+ and TNFR2-deficient Treg cells, researchers identified that Trip13 is required for promoting TNF-TNFR2 pathway-mediated Treg expansion.
S-Nitrosylation of IRF7 Induced by NOS1 Expression in Melanoma Suppresses Anti-Tumor Immunity
[Cell Death & Disease] Scientists found that nitric oxide synthases (NOS) 1 expression induces IRF7 modification by S-nitrosylation at the C435 site in mice, which functionally promotes tumor growth in mouse models.
CircROR1 Binds HNRNPL to Regulate FOXO4 Pre-mRNA Splicing, Promoting Cutaneous Melanoma Metastasis, and Serving As a Therapeutic Target via RNAi-Loaded PEG-LNPs
[Molecular Cancer] Researchers identified circROR1 as an oncogenic circular RNA that plays a crucial role in tumor progression and metastasis.
