[Blood] Leveraging intravital imaging and a murine model of clonal hematopoiesis of indeterminate potential, the authors demonstrated transcriptional and functional compartmentalization of the marrow microenvironment.

[Cell Stem Cell] Researchers found that accrued divisions alter HSC production, generating low-output bone-marrow landscapes that are highly variable in lineage contribution and transcriptionally divergent within individual lineages.

[Journal of Clinical Investigation] Integration of multiomics data revealed that the SCF-F-box only protein 11 (FBXO11) complex regulates spliceosome and ribosome components in a nucleophosmin 1 (NPM1)-centric network.

[Leukemia] Scientists showed that a subset of fetal lymphoid-primed multipotent progenitors expressing the Colony-Stimulating Factor 1 receptor (CSF1R) gives rise to AML upon KMT2A::MLLT3 induction in a mouse model.

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that the chemokine receptor CCR5 is mainly expressed on myeloid-biased HSCs, and therefore, the frequency of CCR5⁺ HSCs increases with age.

[Proceedings of The National Academy of Sciences of The United States of America] The authors identified a key interorgan communication pathway that maintains K⁺ homeostasis and suggests Piezo1–KLHL3 signaling as a potential therapeutic target for treating K⁺ imbalance.

[iScience] Scientists showed that HSC exposed to a single 20 mGy dose of irradiation exhibit, when proliferating, oxidative stress, and altered metabolism associated with increased mitochondrial reactive oxygen species and mitochondrial Ca²⁺ overload.

[The American Journal of Pathology] HasCATs model was developed to identify transcription factors (TFs) that resist HSC aging. This approach revealed RORA as a key aging-negative-associated TF. Rora deletion in HSCs caused aged phenomes and functionally impaired their reconstitutive capacity.

[Aging Cell] The authors integrate recent insights into the mechanisms and systemic impacts of hematopoietic aging, reframing it as a modifiable axis of systemic aging.

[University College London] A newlywed has become the first NHS patient in England with an aggressive form of leukaemia to have the pioneering CAR-T cell therapy – known as ‘obe-cel’ and marketed as Aucatzyl – developed by University College London researchers.

[Gene] Scientists demonstrated that the β-catenin/TCF4 complex significantly enhances miR-302 expression through direct promoter activation in colorectal cancer cells.

[Signal Transduction and Targeted Therapy] Researchers demonstrated that the membrane glycoprotein dysadherin promotes colorectal cancer malignancy by modulating tumor microenvironment acidity.