Keep Current with the Latest in Cell Biology Research

A Self-Renewing Biomimetic Skeletal Muscle Construct Engineered Using Induced Myogenic Progenitor Cells

[Advanced Functional Materials] Utilizing electrospinning, polycaprolactone (PCL) substrates were fabricated to facilitate induced myogenic progenitor cell-differentiation into aligned myotubes by controlling PCL fiber orientation.

Highly Contractile 3D Tissue Engineered Skeletal Muscles From Human iPSCs Reveal Similarities with Primary Myoblast-Derived Tissues

[Stem Cell Reports] Scientists presented a transgene-free method for the generation of purified, expandable myogenic progenitors from human induced pluripotent stem cells grown under feeder-free conditions.

Nuclear Smooth Muscle α-Actin Participates in Vascular Smooth Muscle Cell Differentiation

[Nature Cardiovascular Research] Researchers showed that α-smooth muscle actin localized to the nucleus in wild-type smooth muscle cells (SMCs), enriched in the nucleus with SMC differentiation, and associated with chromatin remodeling complexes and SMC contractile gene promoters.

Circ_0114581 Promotes Osteogenic Differentiation of BMSCs via the MiR-155-5p/HNRNPA3 Axis

[Life Sciences] A competing endogenous RNA regulatory network was obtained through the application of osteoporosis-related high throughput data sets.

Serial Passaging Affects Stromal Cell Mechanosensitivity on Hyaluronic Acid Hydrogels

[Macromolecular Bioscience] Researchers leveraged a methacrylated hyaluronic acid hydrogel platform to study stromal cell mechanotransduction. Hydrogels were first formed through thiol-Michael addition to model normal soft tissue stiffness.

Chemical Hypoxic Preconditioning Improves Survival and Proliferation of Mesenchymal Stem Cells

[Applied Biochemistry and Biotechnology] Investigators used proteomic analysis to explore the molecules that may contribute to the survival and proliferation of hypoxic preconditioned MSCs.

The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs during Simulated Microgravity-Induced Bone Loss

[Advanced Science] By single-cell RNA sequencing, bone marrow-derived MSCs were the most downregulated cell cluster, and coincidentally, Piezo1 expression was mostly enriched in those cells, and was substantially downregulated by unloading.

Engineered Mesenchymal Stem Cell Exosomes Loaded with miR-34c-5p Selectively Promote Eradication of Acute Myeloid Leukemia Stem Cells

[Cancer Letters] The authors employed simultaneous two-step modifications to engineer MSCs and MSC-derived exosomes to create exosomes overexpressing the fused protein lysosome-associated membrane protein 2-interleukin 3 and hematopoietic cell E-selectin/L-selectin ligand.

Antler Stem Cell Exosomes Alleviate Pulmonary Fibrosis via Inhibiting Recruitment of Monocyte Macrophage, Rather than Polarization of M2 Macrophages in Mice

[Cell Death Discovery] Researchers found that administration of antler stem cells improved the survival rate of pulmonary fibrosis mice and reduced lung fibrosis, collagen deposition, and myofibroblast differentiation.

Ginsenoside RG1-Induced Mesenchymal Stem Cells Alleviate Diabetic Cardiomyopathy through Secreting Exosomal circNOTCH1 to Promote Macrophage M2 Polarization

[Phytotherapy Research] A diabetic cardiomyopathy mouse model was constructed, and the effects of ginsenoside RG1-induced MSCs on myocardial function and fibrosis in diabetic mice were evaluated.

Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Osteoarthritis

[Cellular & Molecular Biology Letters] The authors provide a comprehensive overview of the biosynthesis and composition of MSC-Exos and their mechanisms of action in osteoarthritis.

Single-Cell Atlas Reveals Correlates of High Cognitive Function, Dementia, and Resilience to Alzheimer’s Disease Pathology

[Cell] Scientists generated a single-cell transcriptomic atlas of the aged human prefrontal cortex covering 2.3 million cells from postmortem human brain samples of 427 individuals with varying degrees of Alzheimer’s disease pathology and cognitive impairment.

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