[Nature Communications] Investigators used metabolic profiling to discover that diploidization is triggered by an imbalance that arises from a smaller cytoplasmic volume and increased mitochondrial density.

[Cell Reports Methods] Researchers aimed to generate induced neural stem cells from hiPSCs having regional specification restricted to the hindbrain by upregulating hindbrain gene expression and downregulating forebrain and spinal gene expression under minimal growth factor conditions.

[Cell Proliferation] Scientists established human formative pluripotent stem cell-like cells from naïve hESCs, conventional hESCs, hiPSCs, as well as human blastocysts using the three-dimensional Matrigel culture system.

[iScience] Investigators showed that activation of AMP-activated protein kinase (AMPK) or its downstream p38 alone induces naïve conversion.

[Scientific Reports] Researchers used the ANCHOR3 DNA labeling system to track multiple cis-regulatory elements and non-regulatory control regions at different positions in the mouse Klf4 locus.

[Experimental Cell Research] The authors investigated the contribution of nuclear factor erythroid 2-related factor 2 (Nrf2) to adipocyte differentiation using an in vivo teratoma model, a straightforward assay for evaluating the differentiation potential of hESCs.

[European Journal of Human Genetics] Scientists review the challenges and opportunities of using iPSCs to model complex diseases, structured around three key themes: detecting subtle effects, modelling environmental context, and expanding genetic diversity.

[Mount Sinai] Researchers at the Icahn School of Medicine at Mount Sinai have been awarded an $8.2 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) to investigate the earliest developmental origins of the hematopoietic system.

[Biomaterials Advances] To improve wound healing potential, scientists sought to enhance the collagen-glycosaminoglycan scaffold's pro-angiogenic and pro-neurogenic capacity through addition of fibronectin, collagen IV, or laminin 1 to the scaffold, key extracellular matrix components known to support angiogenic and neurogenic processes.

[Biomaterials] Using biofunctional bone matrix models, investigators found that mineralization prevents mesenchymal stem cell-mediated collagen remodeling by limiting actomyosin contractility while promoting osteogenic differentiation.

[Cardiovascular Research] The authors revealed a novel epitranscriptomic pathway wherein YTHDF1 recognizes m⁶A-modified Runx1 mRNA, enhancing its translation and thereby stimulating RUNX1-mediated Ctgf transcription.

[Biofabrication] Inspired by the interactions between the extracellular matrix and growth factors in vivo, this study develops a polyanionic hydrogel system for the controlled delivery of basic fibroblast growth factor to regulate healing processes.