[Cancer Cell] Using genetically engineered mouse models, patient-derived organoids and xenografts, as well as clinical specimens, scientists discovered that colorectal tumors surviving combined KRAS and EGFR inhibition acquire a Paneth-like cell state—a secretory lineage typically confined to the intestinal crypt.

[Molecular Cell] Investigators identified UMP as an endogenous regulator of the orphan nuclear receptor NR4A1 in gastric cancer.

[Cell Reports Medicine] The authors discovered significant nonsense-mediated mRNA decay activation and upregulated SMG5 expression in colorectal cancer.

[Lab On A Chip] A human organoid based bioengineered intestinal epithelium with apical and basolateral partitioning and crypt-axis patterning was characterized with regards to barrier function as well as the presence of key drug-metabolizing enzymes and drug transporters.

[Scientific Reports] Researchers investigated the role of SMAD-specific E3 ubiquitin protein ligase 1 (Smurf1) in regulating gastric cancer progression and revealed its underlying mechanism. Smurf1 expression was analyzed using two publicly available datasets.

[Cancer Chemotherapy and Pharmacology] The authors highlight the multifaceted roles of transient receptor potential melastatin channels in colorectal cancer pathogenesis, their potential as diagnostic and prognostic biomarkers, and their therapeutic applications.

[BeOne Medicines Ltd.] BeOne Medicines Ltd. announced positive top-line results from the Phase III HERIZON-GEA-01 trial evaluating ZIIHERA^® in combination with chemotherapy, with or without TEVIMBRA^®, as first-line treatment for HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma.

[Cell Discovery] Researchers leveraged a large-scale multiomics cohort and a drug screening platform for breast cancer to systematically profile gene fusions.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists showed that METTL3-dependent m6A methylation is essential for maintaining epithelial hierarchy by repressing aberrant luminal gene expression.

[Experimental & Molecular Medicine] The authors identified notable variations in ribosomal protein S24 (RPS24) splicing patterns across breast cancer subtypes and investigated this novel regulatory mechanism.

[Environmental Research] Researchers examined the imidacloprid (IMI) effect on the mammary gland in a peripuberal model where female mice were exposed to IMI.

[Oncogenesis] Investigators found YTH domain-containing family protein 3 (YTHDF3) expression was associated with clinical characteristics of breast cancer patients. YTHDF3 expression influenced the migration and invasion capacity of breast cancer cells in vitro and in vivo.