Keep Current with the Latest in Cell Biology Research
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Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-Ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders
[Analytical Chemistry] Researchers presented a novel workflow to enable interlaboratory studies, comprising live-cell imaging and single-cell isolation, followed by freeze-drying, international shipping, reconstitution, and untargeted lipidomics analysis.
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
[New England Journal of Medicine] Investigators conducted a Phase I–II study of zimislecel in persons with type 1 diabetes. In part A, participants received a half dose of zimislecel as a single infusion into the portal vein, with an option for a second half dose within two years. In parts B and C, participants received a full dose of zimislecel as a single infusion.
Glucose Metabolism and Regulation in Establishing Human Stem Cell-Derived β Cell Maturation
[Cell Reports] Scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity.
Amplia Receives US Ethics Clearance For Pancreatic Cancer Trial
[Amplia Therapeutics] Amplia has received US ethics approval to initiate a Phase II clinical trial of narmafotinib in combination with FOLFIRINOX chemotherapy for advanced pancreatic cancer patients.
Trump Administration Ends Program Critical to Search for an H.I.V. Vaccine
The Trump administration has dealt a sharp blow to work on H.I.V. vaccines, terminating a $258 million program whose work was instrumental to the...
TSC22 Domain Family Member 3 Links Natural Killer Cells to CD8+T Cell-Mediated Drug Hypersensitivity
[Signal Transduction and Targeted Therapy] Scientists highlighted the importance of natural killer cell heterogeneity and TSC22D3 in immune-mediated hypersensitivity disorders, offering potential therapeutic targets for severe cutaneous adverse drug reactions and related conditions.
Enhanced Nano-Vaccine Utilizing Biomineralized Virus-Like Particles for Efficient Glioblastoma Immunotherapy via the Nose-to-Brain Delivery Pathway
[ACS nano] Researchers developed a calcium phosphate (CaP)-covered nanovaccine (NV) based on hepatitis B core antigen derived virus-like particles (HBc VLPs), optimized for mucosal delivery applications.
Magnetic Microcarrier-Based Whole Tumor Cell Vaccines for Tumor Prevention and Immunotherapy
[ACS Nano] This gelatin microcarrier-based vaccine, combined with localized alternating magnetic field-induced hyperthermia, effectively promotes dendritic cell recruitment, enhances immune responses, and effectively inhibits tumor growth.
Effects of Triclosan on Cytokine Production by Human Immune Cells In Vitro
[Environment International] Researchers characterized the effect of triclosan on cytokine responses of peripheral blood mononuclear cells.
Tumor-Specific MHC-II Activates CD4+ and CD8+ T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy
[Cancer Research] Investigators integrated single-cell RNA-sequencing and T cell receptor-sequencing to comprehensively characterize the tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma biopsies prior to a Phase II neoadjuvant immunotherapy clinical trial.
Ultrasonic Cavitation-Manipulated Macrophages Hitchhiking Augments Delivery of Nanocarriers for Active and Efficient Cancer Therapy
[Advanced Healthcare Materials] Scientists presented a promising strategy for efficient cancer therapy by utilizing ultrasound-regulated nanodrug-hitchhiking macrophages.