| Vol. 3.16 – 28 April, 2022 |
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| Scientists demonstrated how high-precision fabrication could enable scaled-down modeling of organ-level cardiac mechanical function. [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified distinct transcription factors that distinguished molecular subtypes of pancreatic cancer, predicted numerous chromatin accessibility peaks associated with gene regulatory networks, discovered regulatory noncoding mutations with potential as cancer drivers. [Nature Communications] |
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| Based on nine biopsy-proven COVID-19 associated nephropathy (COVAN) cases, researchers demonstrated for the first time that APOL1 protein was abundantly expressed in podocytes and glomerular endothelial cells of COVAN kidneys but not in controls. [JCI Insight] |
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| The authors characterized the structural and functional defects of the rare CFTR mutation R352Q – with a potential role contributing to intrapore chloride ion permeation – in patient-derived cell models of the airway and gut. [American Journal of Respiratory Cell and Molecular Biology] |
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| To produce an intestinal metaplasia model in human gastric mucosa in vitro, researchers differentiated hiPSCs to gastric organoids, followed by the overexpression of CDX2 using a tet-on system. [iScience] |
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| The authors showed that neonatal-derived pulmonary SSEA-1+ cells highly expressed lung development-associated genes and had enhanced organoid generation ability compared with the adult cells. [iScience] |
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| Scientists determined the effect of lactate supplementation on the growth, genetic profiles and drug sensitivities of patient-derived organoids from hepatopancreatobiliary tumors. [Cell Death Discovery] |
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| Researchers described an improved differentiation platform to generate retinal organoids from hPSCs at scale and free from time-consuming manual microdissection steps. [Scientific Reports] |
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| Scientists investigated the characteristics and cellular morphology of organoids derived from primary human nasal epithelial cells of chronic rhinosinusitis patients. [Biology Open] |
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| For an organoid culture, an individual organoid, or the cells that compose it, state variables can be characterized, most easily by transcriptomics and by high-content image analysis. [Seminars in Cell & Developmental Biology] |
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| NexImmune, Inc. announced a preclinical research collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center. [NexImmune, Inc.] |
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| May 16 – 19, 2022 Washington, D.C., United States |
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| Duke University – Durham, North Carolina, United States |
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| University of Singapore – Singapore, Singapore |
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| University of Oslo – Oslo, Norway |
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| Harvard University – Cambridge, Massachusetts, United States |
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| City of Hope – Duarte, California, United States |
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