Organoid News Volume 3.16 | Apr 28 2022

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    Britya Ghosh
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    2022-04-28 | ON 3.16


    Organoid News by STEMCELL Technologies
    Vol. 3.16 – 28 April, 2022
    TOP STORY

    Engineering a Living Cardiac Pump on a Chip Using High-Precision Fabrication

    Scientists demonstrated how high-precision fabrication could enable scaled-down modeling of organ-level cardiac mechanical function.
    [Science Advances]

    Full ArticlePress Release

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    PUBLICATIONSRanked by the impact factor of the journal

    Integrated Profiling of Human Pancreatic Cancer Organoids Reveals Chromatin Accessibility Features Associated with Drug Sensitivity

    The authors identified distinct transcription factors that distinguished molecular subtypes of pancreatic cancer, predicted numerous chromatin accessibility peaks associated with gene regulatory networks, discovered regulatory noncoding mutations with potential as cancer drivers.
    [Nature Communications]

    Full Article

    JAK Inhibitor Blocks COVID-19-Cytokine-Induced JAK-STAT-APOL1 Signaling in Glomerular Cells and Podocytopathy in Human Kidney Organoids

    Based on nine biopsy-proven COVID-19 associated nephropathy (COVAN) cases, researchers demonstrated for the first time that APOL1 protein was abundantly expressed in podocytes and glomerular endothelial cells of COVAN kidneys but not in controls.
    [JCI Insight]

    AbstractFull Article

    Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect

    The authors characterized the structural and functional defects of the rare CFTR mutation R352Q – with a potential role contributing to intrapore chloride ion permeation – in patient-derived cell models of the airway and gut.
    [American Journal of Respiratory Cell and Molecular Biology]

    AbstractFull Article

    CDX2-Induced Intestinal Metaplasia in Human Gastric Organoids Derived from Induced Pluripotent Stem Cells

    To produce an intestinal metaplasia model in human gastric mucosa in vitro, researchers differentiated hiPSCs to gastric organoids, followed by the overexpression of CDX2 using a tet-on system.
    [iScience]

    AbstractGraphical Abstract

    Neonatal Lung-Derived SSEA-1+ Cells Exhibited Distinct Stem/Progenitor Characteristics and Organoid Developmental Potential

    The authors showed that neonatal-derived pulmonary SSEA-1+ cells highly expressed lung development-associated genes and had enhanced organoid generation ability compared with the adult cells.
    [iScience]

    AbstractGraphical Abstract

    Lactate Promotes the Growth of Patient-Derived Organoids from Hepatopancreatobiliary Cancers via ENO1/HIF1α Pathway and Does Not Affect Their Drug Sensitivities

    Scientists determined the effect of lactate supplementation on the growth, genetic profiles and drug sensitivities of patient-derived organoids from hepatopancreatobiliary tumors.
    [Cell Death Discovery]

    Full Article

    Generation of 3D Retinal Tissue from Human Pluripotent Stem Cells Using a Directed Small Molecule-Based Serum-Free Microwell Platform

    Researchers described an improved differentiation platform to generate retinal organoids from hPSCs at scale and free from time-consuming manual microdissection steps.
    [Scientific Reports]

    Full Article

    Characterization of Human Nasal Organoids from Chronic Rhinosinusitis Patients

    Scientists investigated the characteristics and cellular morphology of organoids derived from primary human nasal epithelial cells of chronic rhinosinusitis patients.
    [Biology Open]

    Abstract
    Full Article

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    REVIEWS

    Mapping and Exploring the Organoid State Space Using Synthetic Biology

    For an organoid culture, an individual organoid, or the cells that compose it, state variables can be characterized, most easily by transcriptomics and by high-content image analysis.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    NexImmune Announces Preclinical Research Collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center

    NexImmune, Inc. announced a preclinical research collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center.
    [NexImmune, Inc.]

    Press Release

    FEATURED EVENT

    ASGCT 25th Annual Meeting

    May 16 – 19, 2022
    Washington, D.C., United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Heart and Muscle Disease Modeling and Regeneration

    Duke University – Durham, North Carolina, United States

    Research Assistant – Organoids

    University of Singapore – Singapore, Singapore

    Postdoctoral Fellowship – Bioinformatics in Organoid Development

    University of Oslo – Oslo, Norway

    Laboratory Technician – iPSC and Organoid Maintenance

    Harvard University – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Molecular Biology

    City of Hope – Duarte, California, United States

    > See All Jobs

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