 | | Vol. 16.18 – 11 May, 2022 |
| |
|
|
Olfactory Sensory Experience Regulates Gliomagenesis via Neuronal IGF1 | Researchers showed that olfaction could directly regulate gliomagenesis. In an autochthonous mouse model that recapitulated adult gliomagenesis originating in oligodendrocyte precursor cells, gliomas preferentially emerged in the olfactory bulb—the first relay of brain olfactory circuitry.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
Single-Cell Genomic Profiling of Human Dopamine Neurons Identifies a Population That Selectively Degenerates in Parkinson’s Disease | Scientists developed a protocol to enrich and transcriptionally profile dopamine neurons from patients with Parkinson’s disease and matched controls, sampling a total of 387,483 nuclei, including 22,048 dopamine neuron profiles.
[Nature Neuroscience] |
|
|
|
BIN1 Is a Key Regulator of Proinflammatory and Neurodegeneration-Related Activation in Microglia | Bin1 expression was ablated by siRNA knockdown in primary microglial cultures in vitro and Cre-lox mediated conditional deletion in adult mouse brain microglia in vivo.
[Molecular Neurodegeneration] |
|
|
|
Generation of Vascularized Brain Organoids to Study Neurovascular Interactions | The authors induced vessel and brain organoids respectively, and then fused two types of organoids together to obtain vascularized brain organoids.
[eLife] |
|
|
|
Infiltrating Natural Killer Cells Bind, Lyse and Increase Chemotherapy Efficacy in Glioblastoma Stem-Like Tumorospheres | Immunotherapy with super-charged natural killer cells has a potential as antitumor approach. Researchers found their efficiency to kill patient-derived glioblastoma stem-like cells in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients.
[Communications Biology] |
|
|
|
Hyperexcitability in Young iPSC-Derived C9ORF72 Mutant Motor Neurons Is Associated with Increased Intracellular Calcium Release | To better understand neuronal dysfunction during ALS progression, scientists studied motor neuron cultures derived from induced pluripotent stem cells (iPSC) lines generated from C9ORF72 expansion carriers and unaffected controls.
[Scientific Reports] |
|
|
|
Increased miR-155 in Microglial Exosomes Following Heat Stress Accelerates Neuronal Autophagy via Their Transfer Into Neurons | Researchers investigated the underlying mechanism that caused neuronal autophagy upregulation in heat stroke from the perspective of exosome-mediated intercellular communication.
[Frontiers in Neuroscience] |
|
|
|
Knockdown of NUSAP1 Inhibits Cell Proliferation and Invasion through Downregulation of TOP2A in Human Glioblastoma | The authors investigated the expression and biological function of nucleolar and spindle associated protein 1 (NUSAP1) in human glioblastoma, an aggressive brain tumor type with largely ineffective treatment options.
[Cell Cycle] |
|
|
|
The Stem Cell Potential of O-2A Lineage Astroglia | Investigators demonstrated that neural stem-like cells grown in the serum-containing neurobasal medium could differentiate into induced neural-like cells.
[Developmental Neuroscience] |
|
|
|
Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture | To reveal the key factor for satellite glial cells growth and survival, scientists examined the effects of different culture supplementations containing Dulbecco’s Modified Eagle Medium (DMEM)/F12, DMEM high glucose or Neurobasal-A.
[Neurochemical Research] |
|
|
|
|
Reprogramming Neurons for Regeneration: The Fountain of Youth | The authors review some recent findings regarding the roles of genetic cellular state reprogramming in regulation of neural regeneration and explore the potential underlying molecular mechanisms.
[Progress in Neurobiology] |
|
|
|
The Role of Astrocyte Structural Plasticity in Regulating Neural Circuit Function and Behavior | Investigators discuss the emerging evidence linking astrocytic structural plasticity to synaptic circuit remodeling and regulation of behaviors.
[Glia] |
|
|
|
MicroRNAs in Oligodendrocyte Development and Remyelination | Scientists review the role of miRNAs on oligodendrocyte biology and discuss their potential as promising therapeutic tools for remyelination.
[Journal of Neurochemistry] |
|
|
|
|
Western, McGill Team Up in New Neuroscience Initiative | Two of the world’s most accomplished neuroscience research initiatives at McGill and Western University have combined their expertise to take on two large-scale brain research projects.
[Western University] |
|
|
|
Odyssey Health, Inc. Announces Positive Results from Initial Phase I Clinical Trial Subjects for Concussion Drug | Odyssey Health, Inc. announced positive results from the first group of patients dosed with PRV-002, in their Phase I clinical trial.
[Odyssey Group Intl, Inc. (GlobeNewswire, Inc.)] |
|
|
|
|
| June 15 – 18, 2022
San Francisco, California, United States |
|
|
|
|
|
| | McLean Hospital – Belmont, Massachusetts, United States |
|
|
|
| | Leibniz-Forschungsinstitut für Molekulare Pharmakologie – Berlin, Germany |
|
|
|
| | Howard Hughes Medical Institute – New York, New York, United States |
|
|
|
| | Astex Pharmaceuticals Limited – Cambridge, England, United Kingdom |
|
|
|
| | Western University – London, Ontario, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
