Endothelial Cell News 1.13 June 13, 2016 | |
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TOP STORYLymphatic Endothelial Cells Attenuate Inflammation via Suppression of Dendritic Cell Maturation Lymphatic endothelial cell-conditioned media potently suppress dendritic cell maturation with reduced expression of MHCII, CD40, and IL-6, and increased IL-10 and CCL2 expression. [Oncotarget] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers used endothelial progenitor cells (EPCs) overexpressing human telomerase reverse transcriptase (hTERT) for the treatment of diabetes mellitus-induced erectile dysfunction. Rat EPCs were transfected with hTERT (EPCs-hTERT). EPCs-hTERT secreted more growth factors and demonstrated enhanced proliferation and resistance to oxidative stress. [Oncotarget] Full Article Treatment with a highly selective peroxisome proliferator – activated receptor (PPAR)-δ agonist induced proliferation of late endothelial progenitor cells and enhanced their vasculogenic potential. A search for the target molecule of PPAR-δ activation revealed endothelial differentiation gene (Edg)-2. [J Mol Cell Cardiol] Abstract Podxl-deficient lung endothelial cell (EC) cultures exhibit increased permeability to dextran and macrophage transmigration. After thrombin stimulation, ECs lacking Podxl showed delayed recovery of VE-cadherin cell contacts, persistence of F-actin stress fibers, and sustained phosphorylation of the ezrin-radixin-moesin complex and activation of RhoA, suggesting a failure in endothelial barrier stabilization. [Eur J Cell Biol] Abstract The authors investigated the ability of outgrowth endothelial cells in mono-culture or in co-culture with human bone marrow-derived mesenchymal stem cells to form capillary networks in silk fibroin hydrogels. [Biomed Mater] Abstract Scientists investigated the role of TWIST1 and vascular endothelial growth factor A (VEGF-A) in metastasis-associated in colon cancer-1 (MACC1)-induced endothelium-dependent angiogenesis using nude mice with gastric cancer (GC) xenografts, and human umbilical vein endothelial cells that were co-cultured with conditioned media from overexpression and interference MACC1 GC cells. [PLoS One] Full Article This study seeks a better understanding of the role of poly-ADP-ribose polymerase in ischemic and diabetic wound healing, with a specific focus on angiogenesis and vasculogenesis. [J Vasc Surg] Abstract Microvesicles Derived from Alde-Low EPCs Support the Wound Healing Capacity of AT-MSCs The authors demonstrated that microvesicles derived from Alde-Low endothelial progenitor cells (EPCs) possessed the ability to improve the homing ability of non-functional Alde-High EPCs, resulting in wound healing. [Biochem Biophys Res Commun] Abstract Scientists examined the effects of visfatin in oxidized low-density lipoprotein (ox-LDL)-stimulated endothelial progenitor cells (EPCs) as well as the underlying mechanism responsible for these effects. They found that visfatin attenuated the ox-LDL-induced senescence of EPCs by repressing β-galactosidase expression and recovering telomerase activity. [Int J Mol Med] Abstract | |
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REVIEWSThe authors introduce the concepts of physiological and pathological angiogenesis, the crucial role played by the VEGFR-2 pathway in these processes, and the various inhibitors of its activity that have entered the clinical practice. [Pharmacol Ther] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field.
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INDUSTRY NEWSNIH Awards Brown $11.5M for Computational Biology Research With a new five-year, $11.5 million grant from the National Institutes of Health, Brown University will expand its research in computational biology and launch a new Center of Biomedical Research Excellence, which will support five early career faculty members as they tackle the genomics underlying diseases such as cancer, preeclampsia and severe lung infections. [Brown University] Press Release Froedtert & the Medical College of Wisconsin Taps Watson for Clinical Trial Matching IBM announced Froedtert & the Medical College of Wisconsin Cancer Network will adopt Watson cognitive computing to help match cancer patients with clinical trials. The Froedtert & MCW Cancer Network is the first in Wisconsin and among the first cancer programs in the nation to use Watson for Clinical Trial Matching. [IBM] Press Release | |
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EVENTSNEW Gordon Research Conference – Notch Signaling in Development, Regeneration & Disease Visit our events page to see a complete list of events in the endothelial cell community.
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JOB OPPORTUNITIESNEW PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research) Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB) Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine) PhD Position – Physiology (Uppsala University) Fellow/Senior Fellow – Cancer Research (Australian National University) PhD Position – Bioinformatics (VIB) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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