Endothelial Cell News 1.15 June 27, 2016 | |
| |
TOP STORYInvestigators demonstrated that human telomerase reverse transcriptase (hTERT) activates vascular epithelial growth factor (VEGF) gene expression through interactions with the VEGF promoter and the transcription factor Sp1. hTERT binds to Sp1 in vitro and in vivo and stimulates angiogenesis in a manner dependent on Sp1. [Nucleic Acids Res] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Knockdown of taurine upregulated 1 remarkably suppressed tumor-induced endothelial cell proliferation, migration and tube formation as well as reducing spheroid-based angiogenesis ability in vitro, which are the critical steps for tumor angiogenesis. [Oncogene] Abstract Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4 Glutamine withdrawal during vascular differentiation of human embryonic stem cells generated cells with greater angiogenic capacity, thus indicating that modulating glutamine metabolism enhances the differentiation and functional maturation of cells. [Cell Rep] Full Article | Graphical Abstract | Press Release Age-Associated Downregulation of Vasohibin-1 in Vascular Endothelial Cells Researchers examined whether the expression of vasohibin-1 (VASH1) would be affected by aging. They passaged human umbilical vein endothelial cells (HUVECs) and observed that VASH1 was downregulated in old HUVECs. [Aging Cell] Full Article The Anti-Angiogenic Effect and Novel Mechanisms of Action of Combretastatin A-4 Researchers revealed that combretastatin A-4 inhibited vascular endothelial growth factor-induced proliferation, migration and capillary-like tube formation of human umbilical vascular endothelial cells. [Sci Rep] Full Article Scientists demonstrated that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis including proliferation, migration and adhesion. [Sci Rep] Full Article A Non-Canonical Role for Desmoglein-2 in Endothelial Cells: Implications for Neoangiogenesis Researchers revealed that desmogleins is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts in human tissue from healthy individuals and cancer patients. [Angiogenesis] Full Article Circulating endothelial progenitor cell (EPC) were significantly decreased in ANCA-associated vasculitis as compared to healthy controls (HC). The capacity of EPC to differentiate and proliferate was differentially impaired in patients as compared to HC. [Arthritis Res Ther] Full Article Investigators determined if probucol could protect endothelial progenitor cells from oxidized low-density lipoprotein in vivo and investigated the potential mechanisms. [Cell Physiol Biochem] Full Article The authors determined whether the circulating levels of endothelial progenitor cells (EPCs) are changed in the context of Crohn’s disease (CD). CD patients and healthy controls were recruited. Disease activity was assessed by CDAI. Peripheral blood mononuclear cells were isolated and EPC numbers evaluated by FACS analysis using anti-CD34, anti-VEGF receptor-2, anti-CD133, and anti-CD45 markers. [Dig Dis Sci] Abstract | |
| |
REVIEWSThe combination of dynamic contrast-enhanced imaging with mathematical modeling of the contrast agent kinetics enables quantitative assessment of the structural and functional changes in the microvasculature that are associated with tumor angiogenesis. The authors review quantitative imaging of angiogenesis with dynamic contrast-enhanced magnetic resonance imaging, computed tomography, and ultrasound. [IEEE Rev Biomed Eng] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field.
| |
INDUSTRY NEWSVM BioPharma announced the first patient was dosed in the recently initiated Phase III clinical study evaluating VM202, a proprietary DNA based biopharmaceutical, in patients with painful diabetic peripheral neuropathy. [VM BioPharma (PR Newswire Association LLC.)] Press Release Cellular Dynamics International, Inc. announced that it has entered into a CRADA with the National Eye Institute to conduct research to advance a cell transplantation therapy for the treatment of retinal degenerative disease using retinal pigment epithelium derived from induced pluripotent stem cells (iPSC). [Cellular Dynamics International, Inc.] Press Release | |
From our sponsor: Studying ESCs or iPSCs? Request your free copy of the small molecules wallchart.
| |
EVENTSNEW ICCSCE 2016: 18th International Conference on Cell and Stem Cell Engineering Visit our events page to see a complete list of events in the endothelial cell community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Fellow – Immunometabolism (Dalhousie University) NEW Postdoctoral Position – Endothelial Cells (KULeuven) PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research) Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB) Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine) Fellow/Senior Fellow – Cancer Research (Australian National University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Endothelial Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|