Dermal Cell News 2.26 July 18, 2016 | |
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TOP STORYResearchers have for the first time identified mechanisms that determine how advanced melanoma can become resistant to immune checkpoint inhibitors, a discovery that could lead to the development of new and improved treatments for the deadliest type of skin cancer. [Press release from Univeristy of California Los Angeles discussing online prepublication in The New England Journal of Medicine] Press Release | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInvestigators showed that the developing primary hair follicle functions as a niche required for Merkel cell specification. [PLoS Genet] Full Article A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development Scientists found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles. [PLoS Genet] Full Article Improvement of Sclerodermatous Graft versus Host Disease in Mice by Niclosamide Recent reports on the implication of STAT3 and of Wnt/β-catenin in fibrosis have prompted researchers to investigate the effects of the inhibition of both signaling pathways in a mouse model of sclerodermatous GvHD, using niclosamide an anthelmintic drug with well-defined safety profile. [J Invest Dermatol] Abstract Transglutaminase 1 expressions and its substrate were induced in cultured keratinocytes at differentiation-stage specific manner. [Biochem Biophys Res Commun] Abstract SKIN CANCERS & DISORDERSScientists present an analysis of the genetic architecture of normal adult skin from 470 genetically unique mice, demonstrating the effect of germline variants, skin tissue location, and perturbation by exogenous inflammation or tumorigenesis on gene signaling pathways. [Cell Rep] Full Article | Graphical Abstract Investigators showed that the damage-associated molecular pattern High-Mobility Group Box 1 protein is released by melanoma tumor cells as a consequence of hypoxia and promotes M2-like tumor-associated macrophage accumulation and an IL-10 rich milieu within the tumor. [Sci Rep] Full Article IgG Subclass Switching and Clonal Expansion in Cutaneous Melanoma and Normal Skin Researchers found evidence for IgG-expressing B cells, class switching and antibody maturation in normal and malignant skin and clonally-expanded antibodies in melanoma, supporting the involvement of mature B cells in cutaneous immunity. [Sci Rep] Full Article ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma Researchers assessed the underlying mechanism of PREX1 overexpression in human melanoma. [Mol Cancer Res] Abstract Investigators evaluated the effect of mangiferin on metastasis and tumor growth in a mouse metastatic melanoma model. [Toxicol Appl Pharmacol] Abstract | |
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REVIEWSEpigenetic Control of Adult Stem Cell Function The authors explore the effects of epigenetic dysregulation on adult stem cell function. [Nat Rev Mol Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field.
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INDUSTRY NEWSCipher Pharmaceuticals Announces Ozenoxacin Accepted for Review by Health Canada Cipher Pharmaceuticals Inc. announced that its New Drug Submission for Ozenoxacin has been accepted for review by Health Canada. Ozenoxacin is a topical treatment proposed for use in adult and pediatric patients with impetigo, a highly contagious bacterial skin infection. [Cipher Pharmaceuticals Inc.] Press Release Damon Runyon Cancer Research Foundation Awards over $4M to 10 Top Young Clinical Investigators The Damon Runyon Cancer Research Foundation named seven new Damon Runyon Clinical Investigators at its Spring 2016 Clinical Investigator Award committee review. [Damon Runyon Cancer Research Foundation] Press Release | |
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POLICY NEWSPolicy: Five Cornerstones of a Global Bioeconomy Bioscience leaders such as the European Union, Japan and the United States see expanding the bioeconomy as a means of reindustrializing and creating wealth. Emerging industrial economies such as China and India see biotechnology as a nascent field of innovation in which they can quickly compete. Brazil, South Africa and Malaysia are investing to add value to their vast biological resources. [Nature News] Editorial
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EVENTSNEW ICCSCE 2016: 18th International Conference on Cell and Stem Cell Engineering Visit our events page to see a complete list of events in the dermal cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Computational Biology (Helmholtz Association) PhD Studentship – Epithelial Stem Cell Biology (Curtin University) PhD Studentship – Quantitative Biology (University of Heidelberg) Postdoctoral Fellow – Skin Carcinogenesis (Inserm) PhD studentship – Dermal Cell Research (University of Southampton) Postdoctoral Fellow – Modulation of Lipid Organization in the Skin Barrier (Leiden University) Postdoctoral Research Position – Cytokine Research (Temple University Lewis Katz School of Medicine) Postdoctoral Positions – Cell, Developmental & Cancer Biology (Oregon Health & Science University) Postdoctoral Fellow – Tissue Regeneration (US Army Institute of Surgical Research) Research Scientist – Hair Biophysics (L’Oreal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Dermal Cell News Volume 2.26 | Jul 18 2016